3no0: Difference between revisions

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 ==Aquifex aeolicus type IIA topoisomerase C-terminal domain==
-<StructureSection load='3no0' size='340' side='right' caption='[[3no0]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
+<StructureSection load='3no0' size='340' side='right'caption='[[3no0]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3no0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NO0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3no0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NO0 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3004&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aq_980, gyrA, ParC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3no0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3no0 OCA], [https://pdbe.org/3no0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3no0 RCSB], [https://www.ebi.ac.uk/pdbsum/3no0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3no0 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3no0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3no0 OCA], [http://pdbe.org/3no0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3no0 RCSB], [http://www.ebi.ac.uk/pdbsum/3no0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3no0 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GYRA_AQUAE GYRA_AQUAE]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01897]
+[https://www.uniprot.org/uniprot/TOP4A_AQUAE TOP4A_AQUAE] A type II topoisomerase. Despite its similarity to DNA gyrase, this enzyme is not able to supercoil DNA, and instead acts like topoisomerase IV. Relaxes both positively and negatively supercoiled DNA in an ATP-dependent fashion, decatenates interlocked circles. This the first bacteria shown to not contain DNA gyrase, although it has 2 copies of a reverse gyrase that introduces positive supercoils. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (PubMed:21076033).<ref>PMID:21076033</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 21: @@
 ==See Also==
-*[[Gyrase|Gyrase]]
+*[[Gyrase 3D Structures|Gyrase 3D Structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Aquae]]
+[[Category: Aquifex aeolicus VF5]]
-[[Category: Berger, J M]]
+[[Category: Large Structures]]
-[[Category: Lerman, J C]]
+[[Category: Berger JM]]
-[[Category: Tretter, E M]]
+[[Category: Lerman JC]]
-[[Category: Aquifex aeolicus]]
+[[Category: Tretter EM]]
-[[Category: C-terminal domain]]
-[[Category: Dna binding protein]]
-[[Category: Dna topology]]
-[[Category: Gyrase]]
-[[Category: Isomerase]]
-[[Category: Topoisomerase]]