3ezy: Difference between revisions

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'''Unreleased structure'''


The entry 3ezy is ON HOLD
==Crystal structure of probable dehydrogenase TM_0414 from Thermotoga maritima==
 
<StructureSection load='3ezy' size='340' side='right'caption='[[3ezy]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
Authors: Ramagopal, U.A., Toro, R., Freeman, J., Chang, S., Maletic, M., Gheyi, T., Burley, S. K, Almo, S. C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ezy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EZY FirstGlance]. <br>
Description: Crystal structure of probable dehydrogenase TM_0414 from Thermotoga maritima
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  5 11:43:52 2008''
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ezy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ezy OCA], [https://pdbe.org/3ezy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ezy RCSB], [https://www.ebi.ac.uk/pdbsum/3ezy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ezy ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3ezy TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IOLG_THEMA IOLG_THEMA] Catalyzes the NAD(+)-dependent oxidation of myo-inositol (MI) to 2-keto-myo-inositol (scyllo-inosose), and thus probably functions in a myo-inositol degradation pathway together with IolM, IolN and IolO. Has no activity with scyllo-inositol and much reduced activity (78-fold lower catalytic efficiency) with 1D-chiro-inositol.<ref>PMID:23441918</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ez/3ezy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ezy ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Almo SC]]
[[Category: Burley SK]]
[[Category: Chang S]]
[[Category: Freeman J]]
[[Category: Gheyi T]]
[[Category: Maletic M]]
[[Category: Ramagopal UA]]
[[Category: Toro R]]

Latest revision as of 03:27, 28 December 2023

Crystal structure of probable dehydrogenase TM_0414 from Thermotoga maritimaCrystal structure of probable dehydrogenase TM_0414 from Thermotoga maritima

Structural highlights

3ezy is a 4 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.04Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

IOLG_THEMA Catalyzes the NAD(+)-dependent oxidation of myo-inositol (MI) to 2-keto-myo-inositol (scyllo-inosose), and thus probably functions in a myo-inositol degradation pathway together with IolM, IolN and IolO. Has no activity with scyllo-inositol and much reduced activity (78-fold lower catalytic efficiency) with 1D-chiro-inositol.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Rodionova IA, Leyn SA, Burkart MD, Boucher N, Noll KM, Osterman AL, Rodionov DA. Novel inositol catabolic pathway in Thermotoga maritima. Environ Microbiol. 2013 Aug;15(8):2254-66. PMID:23441918 doi:10.1111/1462-2920.12096

3ezy, resolution 2.04Å

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