2oql: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2oql.jpg|left|200px]]<br /><applet load="2oql" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2oql, resolution 1.800&Aring;" />
-'''Structure of Phosphotriesterase mutant H254Q/H257F'''<br />
-==About this Structure==
+==Structure of Phosphotriesterase mutant H254Q/H257F==
-OQL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=BTB:'>BTB</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aryldialkylphosphatase Aryldialkylphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.8.1 3.1.8.1] Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+401'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+402'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+B+401'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Residue+B+402'>AC4</scene>, <scene name='pdbsite=AC5:Btb+Binding+Site+For+Residue+A+701'>AC5</scene>, <scene name='pdbsite=AC6:Btb+Binding+Site+For+Residue+B+701'>AC6</scene>, <scene name='pdbsite=AC7:Gol+Binding+Site+For+Residue+B+801'>AC7</scene>, <scene name='pdbsite=AC8:Gol+Binding+Site+For+Residue+A+802'>AC8</scene> and <scene name='pdbsite=AC9:Gol+Binding+Site+For+Residue+B+803'>AC9</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQL OCA].
+<StructureSection load='2oql' size='340' side='right'caption='[[2oql]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-[[Category: Aryldialkylphosphatase]]
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2oql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OQL FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oql OCA], [https://pdbe.org/2oql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oql RCSB], [https://www.ebi.ac.uk/pdbsum/2oql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oql ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/2oql_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oql ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Brevundimonas diminuta]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Almo, S C.]]
+[[Category: Almo SC]]
-[[Category: Kim, J.]]
+[[Category: Kim J]]
-[[Category: Raushel, F M.]]
+[[Category: Raushel FM]]
-[[Category: Tsai, P.]]
+[[Category: Tsai P]]
-[[Category: BTB]]
-[[Category: GOL]]
-[[Category: ZN]]
-[[Category: hydrolase]]
-[[Category: metalloenzyme]]
-[[Category: nerve agents]]
-[[Category: tim barrel]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:21:31 2008''