2o2t: Difference between revisions

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==The crystal structure of the 1st PDZ domain of MPDZ==
==The crystal structure of the 1st PDZ domain of MPDZ==
<StructureSection load='2o2t' size='340' side='right' caption='[[2o2t]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2o2t' size='340' side='right'caption='[[2o2t]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2o2t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O2T FirstGlance]. <br>
<table><tr><td colspan='2'>[[2o2t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2T FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2t OCA], [http://pdbe.org/2o2t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2o2t RCSB], [http://www.ebi.ac.uk/pdbsum/2o2t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2t ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2t OCA], [https://pdbe.org/2o2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2t RCSB], [https://www.ebi.ac.uk/pdbsum/2o2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN]] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C]]
[[Category: Large Structures]]
[[Category: Berridge, G]]
[[Category: Arrowsmith C]]
[[Category: Doyle, D A]]
[[Category: Berridge G]]
[[Category: Edwards, A]]
[[Category: Doyle DA]]
[[Category: Elkins, J]]
[[Category: Edwards A]]
[[Category: Gileadi, C]]
[[Category: Elkins J]]
[[Category: Gorrec, F]]
[[Category: Gileadi C]]
[[Category: Johansson, C]]
[[Category: Gorrec F]]
[[Category: Papagrigoriou, E]]
[[Category: Johansson C]]
[[Category: Phillips, C]]
[[Category: Papagrigoriou E]]
[[Category: Pike, A C.W]]
[[Category: Phillips C]]
[[Category: Structural genomic]]
[[Category: Pike ACW]]
[[Category: Salah, E]]
[[Category: Salah E]]
[[Category: Savitsky, P]]
[[Category: Savitsky P]]
[[Category: Sundstrom, M]]
[[Category: Sundstrom M]]
[[Category: Umeano, C]]
[[Category: Umeano C]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Sgc]]
[[Category: Structural protein]]

Latest revision as of 03:13, 28 December 2023

The crystal structure of the 1st PDZ domain of MPDZThe crystal structure of the 1st PDZ domain of MPDZ

Structural highlights

2o2t is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MPDZ_HUMAN Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. J Biol Chem. 2001 Apr 20;276(16):12974-82. Epub 2001 Jan 9. PMID:11150294 doi:http://dx.doi.org/10.1074/jbc.M008089200
  2. ↑ Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron. 2004 Aug 19;43(4):563-74. PMID:15312654 doi:10.1016/j.neuron.2004.08.003

2o2t, resolution 2.70Å

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