2o2t: Difference between revisions

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-[[Image:2o2t.gif|left|200px]]
- {{Structure
+==The crystal structure of the 1st PDZ domain of MPDZ==
-|PDB= 2o2t |SIZE=350|CAPTION= <scene name='initialview01'>2o2t</scene>, resolution 2.70&Aring;
+<StructureSection load='2o2t' size='340' side='right'caption='[[2o2t]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2o2t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2T FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-|GENE= MPDZ, MUPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2t OCA], [https://pdbe.org/2o2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2t RCSB], [https://www.ebi.ac.uk/pdbsum/2o2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2t ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2t OCA], [http://www.ebi.ac.uk/pdbsum/2o2t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o2t RCSB]</span>
+[https://www.uniprot.org/uniprot/MPDZ_HUMAN MPDZ_HUMAN] Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<ref>PMID:11150294</ref> <ref>PMID:15312654</ref>
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-'''The crystal structure of the 1st PDZ domain of MPDZ'''
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2t_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-O2T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2T OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o2t ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Berridge, G.]]
+[[Category: Berridge G]]
-[[Category: Doyle, D A.]]
+[[Category: Doyle DA]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Elkins, J.]]
+[[Category: Elkins J]]
-[[Category: Gileadi, C.]]
+[[Category: Gileadi C]]
-[[Category: Gorrec, F.]]
+[[Category: Gorrec F]]
-[[Category: Johansson, C.]]
+[[Category: Johansson C]]
-[[Category: Papagrigoriou, E.]]
+[[Category: Papagrigoriou E]]
-[[Category: Phillips, C.]]
+[[Category: Phillips C]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike ACW]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Salah E]]
-[[Category: Salah, E.]]
+[[Category: Savitsky P]]
-[[Category: Savitsky, P.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Umeano C]]
-[[Category: Umeano, C.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
-[[Category: sgc]]
-[[Category: structural genomic]]
-[[Category: structural genomics consortium]]
-[[Category: structural protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:11:54 2008''