2o21: Difference between revisions

<StructureSection load='2o21' size='340' side='right'caption='[[2o21]]' scene=''>

<table><tr><td colspan='2'>[[2o21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O21 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43B:3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE'>43B</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o21 OCA], [https://pdbe.org/2o21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o21 RCSB], [https://www.ebi.ac.uk/pdbsum/2o21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o21 ProSAT]</span></td></tr>

</table>

[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o21_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o21 ConSurf].

*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]

[[Category: Belli BA]]

[[Category: Bruncko M]]

[[Category: Ding H]]

[[Category: Elmore SW]]

[[Category: Fesik SW]]

[[Category: Joseph MK]]

[[Category: Kunzer A]]

[[Category: Martineau D]]

[[Category: McClellan WJ]]

[[Category: Mitten M]]

[[Category: Ng SC]]

[[Category: Nimmer PM]]

[[Category: Oltersdorf T]]

[[Category: Oost TK]]

[[Category: Park CM]]

[[Category: Petros AM]]

[[Category: Rosenberg SH]]

[[Category: Shoemaker AR]]

[[Category: Song X]]

[[Category: Wang X]]

[[Category: Wendt MD]]

[[Category: Zhang H]]