2o13: Difference between revisions

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-[[Image:2o13.png|left|200px]]
-<!--
+==Solution structure of the C-terminal LIM domain of MLP/CRP3==
-The line below this paragraph, containing "STRUCTURE_2o13", creates the "Structure Box" on the page.
+<StructureSection load='2o13' size='340' side='right'caption='[[2o13]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2o13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O13 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_2o13|  PDB=2o13  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o13 OCA], [https://pdbe.org/2o13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o13 RCSB], [https://www.ebi.ac.uk/pdbsum/2o13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o13 ProSAT]</span></td></tr>
+</table>
-===Solution structure of the C-terminal LIM domain of MLP/CRP3===
+== Disease ==
+[https://www.uniprot.org/uniprot/CSRP3_HUMAN CSRP3_HUMAN] Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M) [MIM:[https://omim.org/entry/607482 607482]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:18505755</ref> <ref>PMID:12507422</ref>   Defects in CSRP3 are the cause of familial hypertrophic cardiomyopathy type 12 (CMH12) [MIM:[https://omim.org/entry/612124 612124]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.<ref>PMID:18505755</ref> <ref>PMID:12642359</ref>
+== Function ==
-==About this Structure==
+[https://www.uniprot.org/uniprot/CSRP3_HUMAN CSRP3_HUMAN] Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity).
-[[2o13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O13 OCA].
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o1/2o13_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o13 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Group:MUZIC:MLP]]
+*[[Muscle LIM protein|Muscle LIM protein]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Edlich, C.]]
+[[Category: Large Structures]]
-[[Category: Muhle-Goll, C.]]
+[[Category: Edlich C]]
-[[Category: Schallus, T.]]
+[[Category: Muhle-Goll C]]
-[[Category: Crp]]
+[[Category: Schallus T]]
-[[Category: Lim domain]]
-[[Category: Metal binding protein]]
-[[Category: Mlp]]
-[[Category: Zinc binding]]