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[[Image:2nxf.gif|left|200px]]


{{Structure
==Crystal Structure of a dimetal phosphatase from Danio rerio LOC 393393==
|PDB= 2nxf |SIZE=350|CAPTION= <scene name='initialview01'>2nxf</scene>, resolution 1.700&Aring;
<StructureSection load='2nxf' size='340' side='right'caption='[[2nxf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[2nxf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NXF FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
|GENE= Dr.12833, LOC 393393 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK11148 PRK11148]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nxf OCA], [https://pdbe.org/2nxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nxf RCSB], [https://www.ebi.ac.uk/pdbsum/2nxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nxf ProSAT], [https://www.topsan.org/Proteins/CESG/2nxf TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nxf OCA], [http://www.ebi.ac.uk/pdbsum/2nxf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nxf RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/ADPRM_DANRE ADPRM_DANRE] Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose.
 
== Evolutionary Conservation ==
'''Crystal Structure of a dimetal phosphatase from Danio rerio LOC 393393'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/2nxf_consurf.spt"</scriptWhenChecked>
2NXF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NXF OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nxf ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bingman, C A.]]
[[Category: Bingman CA]]
[[Category: Bitto, E.]]
[[Category: Bitto E]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: McCoy JG]]
[[Category: Jr., G N.Phillips.]]
[[Category: Phillips Jr GN]]
[[Category: McCoy, J G.]]
[[Category: Wesenberg GE]]
[[Category: Wesenberg, G E.]]
[[Category: center for eukaryotic structural genomic]]
[[Category: cesg]]
[[Category: dinuclear metal center phosphatase]]
[[Category: metallophosphoesterase]]
[[Category: metalloprotein]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:09:46 2008''

Latest revision as of 03:11, 28 December 2023

Crystal Structure of a dimetal phosphatase from Danio rerio LOC 393393Crystal Structure of a dimetal phosphatase from Danio rerio LOC 393393

Structural highlights

2nxf is a 1 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

ADPRM_DANRE Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2nxf, resolution 1.70Å

Drag the structure with the mouse to rotate

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