2cpu: Difference between revisions

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 ==SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT==
-<StructureSection load='2cpu' size='340' side='right' caption='[[2cpu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='2cpu' size='340' side='right'caption='[[2cpu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2cpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CPU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2cpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CPU FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpu OCA], [https://pdbe.org/2cpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cpu RCSB], [https://www.ebi.ac.uk/pdbsum/2cpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cpu ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cpu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cpu RCSB], [http://www.ebi.ac.uk/pdbsum/2cpu PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/AMYP_HUMAN AMYP_HUMAN]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cpu_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/2cpu_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cpu ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 26: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2cpu" style="background-color:#fffaf0;"></div>
-==See Also==
-*[[Amylase|Amylase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Alpha-amylase]]
 [[Category: Homo sapiens]]
-[[Category: Braun, C.]]
+[[Category: Large Structures]]
-[[Category: Brayer, G D.]]
+[[Category: Braun C]]
-[[Category: Maurus, R.]]
+[[Category: Brayer GD]]
-[[Category: Nguyen, N T.]]
+[[Category: Maurus R]]
-[[Category: Overall, C M.]]
+[[Category: Nguyen NT]]
-[[Category: Rydberg, E H.]]
+[[Category: Overall CM]]
-[[Category: Sidhu, G.]]
+[[Category: Rydberg EH]]
-[[Category: Wang, Y.]]
+[[Category: Sidhu G]]
-[[Category: Withers, S G.]]
+[[Category: Wang Y]]
-[[Category: Amylase]]
+[[Category: Withers SG]]
-[[Category: Catalysis]]
-[[Category: Diabetes]]
-[[Category: Enzyme]]
-[[Category: Human]]
-[[Category: Hydrolase]]
-[[Category: Mutagenesis]]
-[[Category: Pancreatic]]