1vqv: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1vqv.gif|left|200px]]<br /><applet load="1vqv" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1vqv, resolution 2.65&Aring;" />
-'''Crystal Structure of Thiamine Monophosphate Kinase (thil) from Aquifex Aeolicus'''<br />
-==About this Structure==
+==Crystal Structure of Thiamine Monophosphate Kinase (thil) from Aquifex Aeolicus==
-VQV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. This structure superseeds the now removed PDB entry 1YAW. Active as [http://en.wikipedia.org/wiki/Thiamine-phosphate_kinase Thiamine-phosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.16 2.7.4.16] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VQV OCA].
+<StructureSection load='1vqv' size='340' side='right'caption='[[1vqv]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1vqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yaw 1yaw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VQV FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vqv OCA], [https://pdbe.org/1vqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vqv RCSB], [https://www.ebi.ac.uk/pdbsum/1vqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vqv ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1vqv TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/THIL_AQUAE THIL_AQUAE] Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.<ref>PMID:18311927</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vq/1vqv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vqv ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Aquifex aeolicus]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Thiamine-phosphate kinase]]
+[[Category: Burley SK]]
-[[Category: Burley, S.K.]]
+[[Category: Eswaramoorthy S]]
-[[Category: Eswaramoorthy, S.]]
+[[Category: Swaminathan S]]
-[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
-[[Category: Swaminathan, S.]]
-[[Category: PO4]]
-[[Category: dimer]]
-[[Category: kinase]]
-[[Category: new york structural genomix research consortium]]
-[[Category: nysgxrc]]
-[[Category: phosphate]]
-[[Category: protein structure initiative]]
-[[Category: psi]]
-[[Category: structural genomics]]
-[[Category: t1881]]
-[[Category: thil]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:02:42 2007''