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==Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA== | ==Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA== | ||
<StructureSection load='1vdl' size='340' side='right'caption='[[1vdl | <StructureSection load='1vdl' size='340' side='right'caption='[[1vdl]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1vdl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1vdl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VDL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdl OCA], [https://pdbe.org/1vdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vdl RCSB], [https://www.ebi.ac.uk/pdbsum/1vdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdl ProSAT], [https://www.topsan.org/Proteins/RSGI/1vdl TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdl OCA], [https://pdbe.org/1vdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vdl RCSB], [https://www.ebi.ac.uk/pdbsum/1vdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdl ProSAT], [https://www.topsan.org/Proteins/RSGI/1vdl TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/UBP25_MOUSE UBP25_MOUSE] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains (By similarity).<ref>PMID:16501887</ref> The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.<ref>PMID:16501887</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Doi-Katayama Y]] | |||
[[Category: Doi-Katayama | [[Category: Hirota H]] | ||
[[Category: Hirota | [[Category: Kigawa T]] | ||
[[Category: Kigawa | [[Category: Koshiba S]] | ||
[[Category: Koshiba | [[Category: Saito K]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Saito | |||
[[Category: Yokoyama | |||
Latest revision as of 03:02, 28 December 2023
Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNASolution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA
Structural highlights
FunctionUBP25_MOUSE Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains (By similarity).[1] The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.[2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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