1vdl: Difference between revisions

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-[[Image:1vdl.gif|left|200px]]<br /><applet load="1vdl" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1vdl" />
-'''Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA'''<br />
-==About this Structure==
+==Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA==
-VDL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Active as [http://en.wikipedia.org/wiki/Ubiquitin_thiolesterase Ubiquitin thiolesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.15 3.1.2.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDL OCA].
+<StructureSection load='1vdl' size='340' side='right'caption='[[1vdl]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1vdl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VDL FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdl OCA], [https://pdbe.org/1vdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vdl RCSB], [https://www.ebi.ac.uk/pdbsum/1vdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdl ProSAT], [https://www.topsan.org/Proteins/RSGI/1vdl TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBP25_MOUSE UBP25_MOUSE] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains (By similarity).<ref>PMID:16501887</ref>   The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.<ref>PMID:16501887</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/1vdl_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vdl ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Thioesterase 3D structures|Thioesterase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Doi-Katayama Y]]
-[[Category: Ubiquitin thiolesterase]]
+[[Category: Hirota H]]
-[[Category: Doi-Katayama, Y.]]
+[[Category: Kigawa T]]
-[[Category: Hirota, H.]]
+[[Category: Koshiba S]]
-[[Category: Kigawa, T.]]
+[[Category: Saito K]]
-[[Category: Koshiba, S.]]
+[[Category: Yokoyama S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
-[[Category: Saito, K.]]
-[[Category: Yokoyama, S.]]
-[[Category: mouse cdna]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomics]]
-[[Category: uba domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:34:14 2008''