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[[Image:1vd0.gif|left|200px]]<br /><applet load="1vd0" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1vd0" />
'''Capsid stabilizing protein GPD, NMR, 20 Structures'''<br />


==About this Structure==
==Capsid stabilizing protein GPD, NMR, 20 Structures==
1VD0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VD0 OCA].  
<StructureSection load='1vd0' size='340' side='right'caption='[[1vd0]]' scene=''>
 
== Structural highlights ==
==Reference==
<table><tr><td colspan='2'>[[1vd0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VD0 FirstGlance]. <br>
NMR solution structure of the monomeric form of the bacteriophage lambda capsid stabilizing protein gpD., Iwai H, Forrer P, Pluckthun A, Guntert P, J Biomol NMR. 2005 Apr;31(4):351-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15929002 15929002]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
[[Category: Enterobacteria phage lambda]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vd0 OCA], [https://pdbe.org/1vd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vd0 RCSB], [https://www.ebi.ac.uk/pdbsum/1vd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vd0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1vd0 TOPSAN]</span></td></tr>
[[Category: Single protein]]
</table>
[[Category: Forrer, P.]]
== Function ==
[[Category: Guntert, P.]]
[https://www.uniprot.org/uniprot/DECO_LAMBD DECO_LAMBD] Stabilizes the expansion of the capsid head shell after genome packaging. The packaging of viral genome in the procapsid triggers a dramatic reconfiguration of the capsid shell, expanding from roughly 50nm to 60nm while the capsid thickness decreases. 415 capsid decoration protein molecules cooperatively bind the expanded capsid, thereby stabilizing the mature capsid shell.<ref>PMID:18786402</ref> <ref>PMID:21821043</ref> <ref>PMID:8411174</ref>
[[Category: Iwai, H.]]
== Evolutionary Conservation ==
[[Category: Pluckthun, A.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
Check<jmol>
[[Category: capsid protein]]
  <jmolCheckbox>
[[Category: national project on protein structural and functional analyses]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/1vd0_consurf.spt"</scriptWhenChecked>
[[Category: nppsfa]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: riken structural genomics/proteomics initiative]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: rsgi]]
  </jmolCheckbox>
[[Category: scottish structural proteomics facility]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vd0 ConSurf].
[[Category: sspf]]
<div style="clear:both"></div>
[[Category: structural genomics]]
== References ==
[[Category: virus/viral protein]]
<references/>
 
__TOC__
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:34:04 2008''
</StructureSection>
[[Category: Escherichia virus Lambda]]
[[Category: Large Structures]]
[[Category: Forrer P]]
[[Category: Guntert P]]
[[Category: Iwai H]]
[[Category: Pluckthun A]]

Latest revision as of 03:01, 28 December 2023

Capsid stabilizing protein GPD, NMR, 20 StructuresCapsid stabilizing protein GPD, NMR, 20 Structures

Structural highlights

1vd0 is a 1 chain structure with sequence from Escherichia virus Lambda. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

DECO_LAMBD Stabilizes the expansion of the capsid head shell after genome packaging. The packaging of viral genome in the procapsid triggers a dramatic reconfiguration of the capsid shell, expanding from roughly 50nm to 60nm while the capsid thickness decreases. 415 capsid decoration protein molecules cooperatively bind the expanded capsid, thereby stabilizing the mature capsid shell.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Lander GC, Evilevitch A, Jeembaeva M, Potter CS, Carragher B, Johnson JE. Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM. Structure. 2008 Sep 10;16(9):1399-406. doi: 10.1016/j.str.2008.05.016. PMID:18786402 doi:http://dx.doi.org/10.1016/j.str.2008.05.016
  2. ↑ Medina EM, Andrews BT, Nakatani E, Catalano CE. The bacteriophage lambda gpNu3 scaffolding protein is an intrinsically disordered and biologically functional procapsid assembly catalyst. J Mol Biol. 2011 Sep 30;412(4):723-36. doi: 10.1016/j.jmb.2011.07.045. Epub 2011 , Jul 29. PMID:21821043 doi:http://dx.doi.org/10.1016/j.jmb.2011.07.045
  3. ↑ Dokland T, Murialdo H. Structural transitions during maturation of bacteriophage lambda capsids. J Mol Biol. 1993 Oct 20;233(4):682-94. PMID:8411174 doi:http://dx.doi.org/10.1006/jmbi.1993.1545
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