1v87: Difference between revisions
New page: left|200px<br /><applet load="1v87" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v87" /> '''Solution Structure of the Ring-H2 Finger Dom... |
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== | ==Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2== | ||
<StructureSection load='1v87' size='340' side='right'caption='[[1v87]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1v87]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V87 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v87 OCA], [https://pdbe.org/1v87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v87 RCSB], [https://www.ebi.ac.uk/pdbsum/1v87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v87 ProSAT], [https://www.topsan.org/Proteins/RSGI/1v87 TOPSAN]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/DTX2_MOUSE DTX2_MOUSE] Recurrent site of retroviral integration in murine B-cell lymphomas. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DTX2_MOUSE DTX2_MOUSE] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/1v87_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v87 ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Inoue M]] | |||
[[Category: Inoue | [[Category: Kigawa T]] | ||
[[Category: Kigawa | [[Category: Koshiba S]] | ||
[[Category: Koshiba | [[Category: Miyamoto K]] | ||
[[Category: Miyamoto | [[Category: Muto Y]] | ||
[[Category: Muto | [[Category: Tochio N]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Tochio | |||
[[Category: Yokoyama | |||
