1v87: Difference between revisions
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==Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2== | |||
<StructureSection load='1v87' size='340' side='right'caption='[[1v87]]' scene=''> | |||
| | == Structural highlights == | ||
| | <table><tr><td colspan='2'>[[1v87]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V87 FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v87 OCA], [https://pdbe.org/1v87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v87 RCSB], [https://www.ebi.ac.uk/pdbsum/1v87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v87 ProSAT], [https://www.topsan.org/Proteins/RSGI/1v87 TOPSAN]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/DTX2_MOUSE DTX2_MOUSE] Recurrent site of retroviral integration in murine B-cell lymphomas. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DTX2_MOUSE DTX2_MOUSE] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
== | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/1v87_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v87 ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Inoue M]] | |||
[[Category: Inoue | [[Category: Kigawa T]] | ||
[[Category: Kigawa | [[Category: Koshiba S]] | ||
[[Category: Koshiba | [[Category: Miyamoto K]] | ||
[[Category: Miyamoto | [[Category: Muto Y]] | ||
[[Category: Muto | [[Category: Tochio N]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Tochio | |||
[[Category: Yokoyama | |||
Latest revision as of 02:59, 28 December 2023
Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2
Structural highlights
DiseaseDTX2_MOUSE Recurrent site of retroviral integration in murine B-cell lymphomas. FunctionDTX2_MOUSE Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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