1ujy: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1ujy.gif|left|200px]]<br />
-<applet load="1ujy" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1ujy" />
-'''Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6'''<br />
-==Disease==
+==Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6==
-Known diseases associated with this structure: Mental retardation, X-linked nonspecific, type 46 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300267 300267]]
+<StructureSection load='1ujy' size='340' side='right'caption='[[1ujy]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1ujy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJY FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujy OCA], [https://pdbe.org/1ujy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujy RCSB], [https://www.ebi.ac.uk/pdbsum/1ujy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujy ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujy TOPSAN]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[https://omim.org/entry/300436 300436]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Acts as a RAC1 guanine nucleotide exchange factor (GEF).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uj/1ujy_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ujy ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-UJY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA].
+*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Aoki, M.]]
+[[Category: Aoki M]]
-[[Category: He, F.]]
+[[Category: He F]]
-[[Category: Hirota, H.]]
+[[Category: Hirota H]]
-[[Category: Inoue, M.]]
+[[Category: Inoue M]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa T]]
-[[Category: Kikuno, R.]]
+[[Category: Kikuno R]]
-[[Category: Kobayashi, N.]]
+[[Category: Kobayashi N]]
-[[Category: Koshiba, S.]]
+[[Category: Koshiba S]]
-[[Category: Matsuda, T.]]
+[[Category: Matsuda T]]
-[[Category: Matsuo, Y.]]
+[[Category: Matsuo Y]]
-[[Category: Muto, Y.]]
+[[Category: Muto Y]]
-[[Category: Nagase, T.]]
+[[Category: Nagase T]]
-[[Category: Nagayama, M.]]
+[[Category: Nagayama M]]
-[[Category: Ohara, O.]]
+[[Category: Ohara O]]
-[[Category: Osanai, T.]]
+[[Category: Osanai T]]
-[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+[[Category: Seki E]]
-[[Category: Seki, E.]]
+[[Category: Shirouzu M]]
-[[Category: Shirouzu, M.]]
+[[Category: Tanaka A]]
-[[Category: Tanaka, A.]]
+[[Category: Terada T]]
-[[Category: Terada, T.]]
+[[Category: Uda H]]
-[[Category: Uda, H.]]
+[[Category: Yabuki T]]
-[[Category: Yabuki, T.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
+[[Category: Yoshida M]]
-[[Category: Yoshida, M.]]
-[[Category: gef 6]]
-[[Category: nmr]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: sh3 domain]]
-[[Category: structural genomics]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:35:53 2007''