1uhs: Difference between revisions

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-[[Image:1uhs.jpg|left|200px]]
- {{Structure
+==Solution structure of mouse homeodomain-only protein HOP==
-|PDB= 1uhs |SIZE=350|CAPTION= <scene name='initialview01'>1uhs</scene>
+<StructureSection load='1uhs' size='340' side='right'caption='[[1uhs]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1uhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHS FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE= RIKEN cDNA 1110018K11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhs OCA], [https://pdbe.org/1uhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhs RCSB], [https://www.ebi.ac.uk/pdbsum/1uhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhs ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhs TOPSAN]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhs OCA], [http://www.ebi.ac.uk/pdbsum/1uhs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uhs RCSB]</span>
+[https://www.uniprot.org/uniprot/HOP_MOUSE HOP_MOUSE] Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.<ref>PMID:12297045</ref> <ref>PMID:12297046</ref>
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhs_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhs ConSurf].
+<div style="clear:both"></div>
-'''Solution structure of mouse homeodomain-only protein HOP'''
+==See Also==
+*[[HOP protein|HOP protein]]
+== References ==
-==About this Structure==
+<references/>
-UHS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHS OCA].
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Aoki M]]
-[[Category: Aoki, M.]]
+[[Category: Arakawa T]]
-[[Category: Arakawa, T.]]
+[[Category: Carninci P]]
-[[Category: Carninci, P.]]
+[[Category: Hayashizaki Y]]
-[[Category: Hayashizaki, Y.]]
+[[Category: Hirota H]]
-[[Category: Hirota, H.]]
+[[Category: Inoue M]]
-[[Category: Inoue, M.]]
+[[Category: Kawai J]]
-[[Category: Kawai, J.]]
+[[Category: Kigawa T]]
-[[Category: Kigawa, T.]]
+[[Category: Koshiba S]]
-[[Category: Koshiba, S.]]
+[[Category: Matsuda T]]
-[[Category: Matsuda, T.]]
+[[Category: Osanai T]]
-[[Category: Osanai, T.]]
+[[Category: Saito K]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Seki E]]
-[[Category: Saito, K.]]
+[[Category: Shirouzu M]]
-[[Category: Seki, E.]]
+[[Category: Tanaka A]]
-[[Category: Shirouzu, M.]]
+[[Category: Terada T]]
-[[Category: Tanaka, A.]]
+[[Category: Yabuki T]]
-[[Category: Terada, T.]]
+[[Category: Yokoyama S]]
-[[Category: Yabuki, T.]]
+[[Category: Yoshida M]]
-[[Category: Yokoyama, S.]]
-[[Category: Yoshida, M.]]
-[[Category: cardiac development]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:10:28 2008''