1uhf: Difference between revisions

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-[[Image:1uhf.png|left|200px]]
-{{STRUCTURE_1uhf|  PDB=1uhf  |  SCENE=  }}
+==Solution Structure of the third SH3 domain of human intersectin 2(KIAA1256)==
+<StructureSection load='1uhf' size='340' side='right'caption='[[1uhf]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1uhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhf OCA], [https://pdbe.org/1uhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhf RCSB], [https://www.ebi.ac.uk/pdbsum/1uhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhf ProSAT], [https://www.topsan.org/Proteins/RSGI/1uhf TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhf ConSurf].
+<div style="clear:both"></div>
-===Solution Structure of the third SH3 domain of human intersectin 2(KIAA1256)===
+==See Also==
+*[[Intersectin|Intersectin]]
+== References ==
-==About this Structure==
+<references/>
-[[1uhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHF OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Hatanaka, H.]]
+[[Category: Large Structures]]
-[[Category: Inoue, M.]]
+[[Category: Hatanaka H]]
-[[Category: Kigawa, T.]]
+[[Category: Inoue M]]
-[[Category: Koshiba, S.]]
+[[Category: Kigawa T]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Koshiba S]]
-[[Category: Shirouzu, M.]]
+[[Category: Shirouzu M]]
-[[Category: Suzuki, S.]]
+[[Category: Suzuki S]]
-[[Category: Terada, T.]]
+[[Category: Terada T]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama S]]
-[[Category: Beta barrel]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Sh3 domain]]
-[[Category: Signaling protein]]
-[[Category: Structural genomic]]