1uep: Difference between revisions

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-[[Image:1uep.png|left|200px]]
-{{STRUCTURE_1uep|  PDB=1uep  |  SCENE=  }}
+==Solution Structure of The Third PDZ Domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 Protein)==
+<StructureSection load='1uep' size='340' side='right'caption='[[1uep]]' scene=''>
-===Solution Structure of The Third PDZ Domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 Protein)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1uep]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UEP FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uep OCA], [https://pdbe.org/1uep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uep RCSB], [https://www.ebi.ac.uk/pdbsum/1uep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uep ProSAT], [https://www.topsan.org/Proteins/RSGI/1uep TOPSAN]</span></td></tr>
-[[1uep]] is a 1 chain structure of [[Guanylate kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEP OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MAGI2_HUMAN MAGI2_HUMAN] Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.<ref>PMID:10760291</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ue/1uep_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uep ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Guanylate kinase|Guanylate kinase]]
+*[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Inoue, M.]]
+[[Category: Large Structures]]
-[[Category: Kigawa, T.]]
+[[Category: Inoue M]]
-[[Category: Koshiba, S.]]
+[[Category: Kigawa T]]
-[[Category: Miyamoto, K.]]
+[[Category: Koshiba S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Miyamoto K]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama S]]
-[[Category: Atrophin-1 interacting protein 1]]
-[[Category: Pdz domain]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Signaling protein]]
-[[Category: Structural genomic]]