1ua7: Difference between revisions

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-{{Seed}}
-[[Image:1ua7.png|left|200px]]
-<!--
+==Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose==
-The line below this paragraph, containing "STRUCTURE_1ua7", creates the "Structure Box" on the page.
+<StructureSection load='1ua7' size='340' side='right'caption='[[1ua7]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ua7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UA7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACI:6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL'>ACI</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G6D:6-DEOXY-ALPHA-D-GLUCOSE'>G6D</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GLD:4,6-DIDEOXYGLUCOSE'>GLD</scene></td></tr>
-{{STRUCTURE_1ua7|  PDB=1ua7  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ua7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ua7 OCA], [https://pdbe.org/1ua7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ua7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ua7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ua7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AMY_BACSU AMY_BACSU]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1ua7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ua7 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structure of Bacillus subtilis alpha-amylase, in complex with the pseudotetrasaccharide inhibitor acarbose, revealed an hexasaccharide in the active site as a result of transglycosylation. After comparison with the known structure of the catalytic-site mutant complexed with the native substrate maltopentaose, it is suggested that the present structure represents a mimic intermediate in the initial stage of the catalytic process.
-===Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose===
+Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose.,Kagawa M, Fujimoto Z, Momma M, Takase K, Mizuno H J Bacteriol. 2003 Dec;185(23):6981-4. PMID:14617662<ref>PMID:14617662</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1ua7" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_14617662}}, adds the Publication Abstract to the page
+*[[Amylase 3D structures|Amylase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 14617662 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_14617662}}
+__TOC__
+</StructureSection>
-==About this Structure==
-UA7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UA7 OCA].
-==Reference==
-<ref group="xtra">PMID:14617662</ref><references group="xtra"/>
-[[Category: Alpha-amylase]]
 [[Category: Bacillus subtilis]]
-[[Category: Fujimoto, Z.]]
+[[Category: Large Structures]]
-[[Category: Kagawa, M.]]
+[[Category: Fujimoto Z]]
-[[Category: Mizuno, H.]]
+[[Category: Kagawa M]]
-[[Category: Momma, M.]]
+[[Category: Mizuno H]]
-[[Category: Takase, K.]]
+[[Category: Momma M]]
-[[Category: Acarbose]]
+[[Category: Takase K]]
-[[Category: Beta-alpha-barrel]]
-[[Category: Greek-key motif]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:20:38 2009''