1u2f: Difference between revisions

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OCA

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 ==SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN OF HU2AF65==
-<StructureSection load='1u2f' size='340' side='right'caption='[[1u2f]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+<StructureSection load='1u2f' size='340' side='right'caption='[[1u2f]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1u2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U2F FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1u2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U2F FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2u2f|2u2f]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u2f OCA], [https://pdbe.org/1u2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u2f RCSB], [https://www.ebi.ac.uk/pdbsum/1u2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u2f ProSAT], [https://www.topsan.org/Proteins/RSGI/1u2f TOPSAN]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
+[https://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Green, M R]]
+[[Category: Green MR]]
-[[Category: Ito, T]]
+[[Category: Ito T]]
-[[Category: Muto, Y]]
+[[Category: Muto Y]]
-[[Category: Structural genomic]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S]]
-[[Category: Rbd]]
-[[Category: Rna binding protein]]
-[[Category: Rna-binding protein]]
-[[Category: Rsgi]]
-[[Category: Splicing]]
-[[Category: U2 snrnp]]