1qhb: Difference between revisions

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-{{Seed}}
-[[Image:1qhb.png|left|200px]]
-<!--
+==VANADIUM BROMOPEROXIDASE FROM RED ALGA CORALLINA OFFICINALIS==
-The line below this paragraph, containing "STRUCTURE_1qhb", creates the "Structure Box" on the page.
+<StructureSection load='1qhb' size='340' side='right'caption='[[1qhb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1qhb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Corallina_officinalis Corallina officinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QHB FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-{{STRUCTURE_1qhb|  PDB=1qhb  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qhb OCA], [https://pdbe.org/1qhb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qhb RCSB], [https://www.ebi.ac.uk/pdbsum/1qhb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qhb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRXV_COROI PRXV_COROI] Catalyzes the halogenation of organic substrates in the presence of hydrogen peroxide.<ref>PMID:12121762</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qh/1qhb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qhb ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The three-dimensional structure of the vanadium bromoperoxidase protein from the marine red macroalgae Corallina officinalis has been determined by single isomorphous replacement at 2.3 A resolution. The enzyme subunit is made up of 595 amino acid residues folded into a single alpha+beta domain. There are 12 bromoperoxidase subunits, arranged with 23-point group symmetry. A cavity is formed by the N terminus of each subunit in the centre of the dodecamer. The subunit fold and dimer organisation of the Cor. officinalis vanadium bromoperoxidase are similar to those of the dimeric enzyme from the brown algae Ascophyllum nodosum, with which it shares 33 % sequence identity. The different oligomeric state of the two algal enzymes seems to reflect separate mechanisms of adaptation to harsh environmental conditions and/or to chemically active substrates and products. The residues involved in the vanadate binding are conserved between the two algal bromoperoxidases and the vanadium chloroperoxidase from the fungus Curvularia inaequalis. However, most of the other residues forming the active-site cavity are different in the three enzymes, which reflects differences in the substrate specificity and stereoselectivity of the reaction. A dimer of the Cor. officinalis enzyme partially superimposes with the two-domain monomer of the fungal enzyme.
-===VANADIUM BROMOPEROXIDASE FROM RED ALGA CORALLINA OFFICINALIS===
+Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis.,Isupov MN, Dalby AR, Brindley AA, Izumi Y, Tanabe T, Murshudov GN, Littlechild JA J Mol Biol. 2000 Jun 16;299(4):1035-49. PMID:10843856<ref>PMID:10843856</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1qhb" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_10843856}}, adds the Publication Abstract to the page
+*[[Haloperoxidase|Haloperoxidase]]
-(as it appears on PubMed at http://www.pubmed.gov), where 10843856 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_10843856}}
+__TOC__
+</StructureSection>
-==About this Structure==
-QHB is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Corallina_officinalis Corallina officinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHB OCA].
-==Reference==
-<ref group="xtra">PMID:10843856</ref><references group="xtra"/>
-[[Category: Chloride peroxidase]]
 [[Category: Corallina officinalis]]
-[[Category: Brindley, A A.]]
+[[Category: Large Structures]]
-[[Category: Dalby, A R.]]
+[[Category: Brindley AA]]
-[[Category: Isupov, M N.]]
+[[Category: Dalby AR]]
-[[Category: Littlechild, J A.]]
+[[Category: Isupov MN]]
-[[Category: Halogenation]]
+[[Category: Littlechild JA]]
-[[Category: Red alga]]
-[[Category: Vanadium-dependent]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:51:54 2009''