1mms: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1mms.png|left|200px]]
-{{STRUCTURE_1mms|  PDB=1mms  |  SCENE=  }}
+==Crystal structure of the ribosomal PROTEIN L11-RNA complex==
+<StructureSection load='1mms' size='340' side='right'caption='[[1mms]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1mms]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MMS FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mms OCA], [https://pdbe.org/1mms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mms RCSB], [https://www.ebi.ac.uk/pdbsum/1mms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mms ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RL11_THEMA RL11_THEMA] This protein binds directly to 23S ribosomal RNA.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mm/1mms_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mms ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We report the crystal structure of a 58 nucleotide fragment of 23S ribosomal RNA bound to ribosomal protein L11. This highly conserved ribonucleoprotein domain is the target for the thiostrepton family of antibiotics that disrupt elongation factor function. The highly compact RNA has both familiar and novel structural motifs. While the C-terminal domain of L11 binds RNA tightly, the N-terminal domain makes only limited contacts with RNA and is proposed to function as a switch that reversibly associates with an adjacent region of RNA. The sites of mutations conferring resistance to thiostrepton and micrococcin line a narrow cleft between the RNA and the N-terminal domain. These antibiotics are proposed to bind in this cleft, locking the putative switch and interfering with the function of elongation factors.
-===Crystal structure of the ribosomal PROTEIN L11-RNA complex===
+A detailed view of a ribosomal active site: the structure of the L11-RNA complex.,Wimberly BT, Guymon R, McCutcheon JP, White SW, Ramakrishnan V Cell. 1999 May 14;97(4):491-502. PMID:10338213<ref>PMID:10338213</ref>
-{{ABSTRACT_PUBMED_10338213}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1mms" style="background-color:#fffaf0;"></div>
-[[1mms]] is a 4 chain structure of [[Ribosomal protein L11]] with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMS OCA].
 ==See Also==
-*[[Ribosomal protein L11|Ribosomal protein L11]]
+*[[Ribosomal protein L11 3D structures|Ribosomal protein L11 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:010338213</ref><ref group="xtra">PMID:011907568</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Thermotoga maritima]]
-[[Category: Guymon, R.]]
+[[Category: Guymon R]]
-[[Category: Mccutcheon, J P.]]
+[[Category: Mccutcheon JP]]
-[[Category: Ramakrishnan, V.]]
+[[Category: Ramakrishnan V]]
-[[Category: White, S W.]]
+[[Category: White SW]]
-[[Category: Wimberly, B T.]]
+[[Category: Wimberly BT]]
-[[Category: Ribosome]]
-[[Category: Rna]]
-[[Category: Rna-protein complex]]
-[[Category: Thiostrepton]]
-[[Category: Translocation]]