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[[Image:1kp6.png|left|200px]]


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==USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT==
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<StructureSection load='1kp6' size='340' side='right'caption='[[1kp6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1kp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ustilago_maydis Ustilago maydis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KP6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1kp6|  PDB=1kp6  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kp6 OCA], [https://pdbe.org/1kp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kp6 RCSB], [https://www.ebi.ac.uk/pdbsum/1kp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kp6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KP6T_UMV6 KP6T_UMV6] This protein is lethal to sensitive cells of the same or related species. The KP6 alpha subunit is known to recognize some cellular receptors before interaction of the complex with KP6 beta, precipitating cell death.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ustilago maydis is a fungal pathogen of maize, some strains of which secrete killer toxins. The toxins are encoded by double-stranded RNA viruses in the cell cytoplasm. The U. maydis killer toxin KP6 contains two polypeptide chains, alpha and beta, having 79 and 81 amino acids, respectively, both of which are necessary for its killer activity. The crystal structure of the alpha-subunit of KP6 (KP6alpha) has been determined at 1.80-A resolution. KP6alpha forms a single domain structure that has an overall shape of an ellipsoid with dimensions 40 A x 26 A x 21 A and belongs to the alpha/beta-sandwich family. The tertiary structure consists of a four-stranded antiparallel beta-sheet, a pair of antiparallel alpha-helices, a short strand along one edge of the sheet, and a short N-terminal helix. Although the fold is reminiscent of toxins of similar size, the topology of KP6alpha is distinctly different in that the alpha/beta-sandwich motif has two right-handed betaalphabeta split crossovers. Monomers of KP6alpha assemble through crystallographic symmetries, forming a hexamer with a central pore lined by hydrophobic N-terminal helices. The central pore could play an important role in the mechanism of the killing action of the toxin.


===USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT===
Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore.,Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:10400668<ref>PMID:10400668</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1kp6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
{{ABSTRACT_PUBMED_10400668}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1KP6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ustilago_maydis Ustilago maydis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KP6 OCA].
 
==Reference==
Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore., Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D, J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10400668 10400668]
[[Category: Single protein]]
[[Category: Ustilago maydis]]
[[Category: Ustilago maydis]]
[[Category: Bruenn, J.]]
[[Category: Bruenn J]]
[[Category: Duax, W L.]]
[[Category: Duax WL]]
[[Category: Erman, M.]]
[[Category: Erman M]]
[[Category: Ghosh, D.]]
[[Category: Ghosh D]]
[[Category: Li, N.]]
[[Category: Li N]]
[[Category: Pangborn, W.]]
[[Category: Pangborn W]]
[[Category: Park, C M.]]
[[Category: Park C-M]]
[[Category: Ion channel modulator]]
[[Category: Killer toxin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 10:41:45 2008''

Latest revision as of 02:43, 28 December 2023

USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNITUSTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT

Structural highlights

1kp6 is a 1 chain structure with sequence from Ustilago maydis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KP6T_UMV6 This protein is lethal to sensitive cells of the same or related species. The KP6 alpha subunit is known to recognize some cellular receptors before interaction of the complex with KP6 beta, precipitating cell death.

Publication Abstract from PubMed

Ustilago maydis is a fungal pathogen of maize, some strains of which secrete killer toxins. The toxins are encoded by double-stranded RNA viruses in the cell cytoplasm. The U. maydis killer toxin KP6 contains two polypeptide chains, alpha and beta, having 79 and 81 amino acids, respectively, both of which are necessary for its killer activity. The crystal structure of the alpha-subunit of KP6 (KP6alpha) has been determined at 1.80-A resolution. KP6alpha forms a single domain structure that has an overall shape of an ellipsoid with dimensions 40 A x 26 A x 21 A and belongs to the alpha/beta-sandwich family. The tertiary structure consists of a four-stranded antiparallel beta-sheet, a pair of antiparallel alpha-helices, a short strand along one edge of the sheet, and a short N-terminal helix. Although the fold is reminiscent of toxins of similar size, the topology of KP6alpha is distinctly different in that the alpha/beta-sandwich motif has two right-handed betaalphabeta split crossovers. Monomers of KP6alpha assemble through crystallographic symmetries, forming a hexamer with a central pore lined by hydrophobic N-terminal helices. The central pore could play an important role in the mechanism of the killing action of the toxin.

Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore.,Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:10400668[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D. Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore. J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:10400668

1kp6, resolution 1.80Å

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