1kp6: Difference between revisions

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-[[Image:1kp6.jpg|left|200px]]
-<!--
+==USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT==
-The line below this paragraph, containing "STRUCTURE_1kp6", creates the "Structure Box" on the page.
+<StructureSection load='1kp6' size='340' side='right'caption='[[1kp6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1kp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ustilago_maydis Ustilago maydis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KP6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1kp6|  PDB=1kp6  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kp6 OCA], [https://pdbe.org/1kp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kp6 RCSB], [https://www.ebi.ac.uk/pdbsum/1kp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kp6 ProSAT]</span></td></tr>
+</table>
-'''USTILAGO MAYDIS KILLER TOXIN KP6 ALPHA-SUBUNIT'''
+== Function ==
+[https://www.uniprot.org/uniprot/KP6T_UMV6 KP6T_UMV6] This protein is lethal to sensitive cells of the same or related species. The KP6 alpha subunit is known to recognize some cellular receptors before interaction of the complex with KP6 beta, precipitating cell death.
+<div style="background-color:#fffaf0;">
-==Overview==
+== Publication Abstract from PubMed ==
 Ustilago maydis is a fungal pathogen of maize, some strains of which secrete killer toxins. The toxins are encoded by double-stranded RNA viruses in the cell cytoplasm. The U. maydis killer toxin KP6 contains two polypeptide chains, alpha and beta, having 79 and 81 amino acids, respectively, both of which are necessary for its killer activity. The crystal structure of the alpha-subunit of KP6 (KP6alpha) has been determined at 1.80-A resolution. KP6alpha forms a single domain structure that has an overall shape of an ellipsoid with dimensions 40 A x 26 A x 21 A and belongs to the alpha/beta-sandwich family. The tertiary structure consists of a four-stranded antiparallel beta-sheet, a pair of antiparallel alpha-helices, a short strand along one edge of the sheet, and a short N-terminal helix. Although the fold is reminiscent of toxins of similar size, the topology of KP6alpha is distinctly different in that the alpha/beta-sandwich motif has two right-handed betaalphabeta split crossovers. Monomers of KP6alpha assemble through crystallographic symmetries, forming a hexamer with a central pore lined by hydrophobic N-terminal helices. The central pore could play an important role in the mechanism of the killing action of the toxin.
-==About this Structure==
+Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore.,Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:10400668<ref>PMID:10400668</ref>
-KP6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ustilago_maydis Ustilago maydis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KP6 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Structure of Ustilago maydis killer toxin KP6 alpha-subunit. A multimeric assembly with a central pore., Li N, Erman M, Pangborn W, Duax WL, Park CM, Bruenn J, Ghosh D, J Biol Chem. 1999 Jul 16;274(29):20425-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10400668 10400668]
+</div>
-[[Category: Single protein]]
+<div class="pdbe-citations 1kp6" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Ustilago maydis]]
-[[Category: Bruenn, J.]]
+[[Category: Bruenn J]]
-[[Category: Duax, W L.]]
+[[Category: Duax WL]]
-[[Category: Erman, M.]]
+[[Category: Erman M]]
-[[Category: Ghosh, D.]]
+[[Category: Ghosh D]]
-[[Category: Li, N.]]
+[[Category: Li N]]
-[[Category: Pangborn, W.]]
+[[Category: Pangborn W]]
-[[Category: Park, C M.]]
+[[Category: Park C-M]]
-[[Category: Ion channel modulator]]
-[[Category: Killer toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:00:21 2008''