1j2n: Difference between revisions

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==Solution structure of CPI-17(22-120) T38D==
==Solution structure of CPI-17(22-120) T38D==
<StructureSection load='1j2n' size='340' side='right' caption='[[1j2n]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1j2n' size='340' side='right'caption='[[1j2n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1j2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J2N FirstGlance]. <br>
<table><tr><td colspan='2'>[[1j2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J2N FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j2m|1j2m]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2n OCA], [http://pdbe.org/1j2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j2n RCSB], [http://www.ebi.ac.uk/pdbsum/1j2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2n OCA], [https://pdbe.org/1j2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j2n RCSB], [https://www.ebi.ac.uk/pdbsum/1j2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PP14A_PIG PP14A_PIG]] Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.<ref>PMID:9237662</ref> <ref>PMID:8720121</ref> <ref>PMID:10924361</ref> <ref>PMID:10869555</ref>
[https://www.uniprot.org/uniprot/PP14A_PIG PP14A_PIG] Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.<ref>PMID:9237662</ref> <ref>PMID:8720121</ref> <ref>PMID:10924361</ref> <ref>PMID:10869555</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/1j2n_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/1j2n_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pig]]
[[Category: Large Structures]]
[[Category: Brautigan, D L]]
[[Category: Sus scrofa]]
[[Category: Eto, M]]
[[Category: Brautigan DL]]
[[Category: Kainosho, M]]
[[Category: Eto M]]
[[Category: Ohki, S]]
[[Category: Kainosho M]]
[[Category: Shimizu, M]]
[[Category: Ohki S]]
[[Category: Takada, R]]
[[Category: Shimizu M]]
[[Category: Helix bundle]]
[[Category: Takada R]]
[[Category: Protein binding]]

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