1iu2: Difference between revisions
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==The first PDZ domain of PSD-95== | ==The first PDZ domain of PSD-95== | ||
<StructureSection load='1iu2' size='340' side='right' caption='[[1iu2 | <StructureSection load='1iu2' size='340' side='right'caption='[[1iu2]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1iu2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1iu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IU2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iu2 OCA], [https://pdbe.org/1iu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iu2 RCSB], [https://www.ebi.ac.uk/pdbsum/1iu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iu2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/1iu2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/1iu2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1iu2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1iu2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Long | [[Category: Rattus norvegicus]] | ||
[[Category: Niethammer | [[Category: Long J-F]] | ||
[[Category: Sala | [[Category: Niethammer M]] | ||
[[Category: Sheng | [[Category: Sala C]] | ||
[[Category: Tochio | [[Category: Sheng M]] | ||
[[Category: Wang | [[Category: Tochio H]] | ||
[[Category: Zhang | [[Category: Wang P]] | ||
[[Category: Zhang M]] | |||