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==The first PDZ domain of PSD-95==
==The first PDZ domain of PSD-95==
<StructureSection load='1iu0' size='340' side='right'caption='[[1iu0]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1iu0' size='340' side='right'caption='[[1iu0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1iu0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IU0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1iu0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IU0 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iu2|1iu2]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iu0 OCA], [https://pdbe.org/1iu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iu0 RCSB], [https://www.ebi.ac.uk/pdbsum/1iu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iu0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iu0 OCA], [https://pdbe.org/1iu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iu0 RCSB], [https://www.ebi.ac.uk/pdbsum/1iu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iu0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1iu0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1iu0" style="background-color:#fffaf0;"></div>
==See Also==
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Long, J F]]
[[Category: Rattus norvegicus]]
[[Category: Niethammer, M]]
[[Category: Long J-F]]
[[Category: Sala, C]]
[[Category: Niethammer M]]
[[Category: Sheng, M]]
[[Category: Sala C]]
[[Category: Tochio, H]]
[[Category: Sheng M]]
[[Category: Wang, P]]
[[Category: Tochio H]]
[[Category: Zhang, M]]
[[Category: Wang P]]
[[Category: Neuropeptide]]
[[Category: Zhang M]]
[[Category: Pdz domain]]
[[Category: Post synaptic density]]
[[Category: Psd-95]]

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