1gjh: Difference between revisions

<StructureSection load='1gjh' size='340' side='right'caption='[[1gjh]]' scene=''>

<table><tr><td colspan='2'>[[1gjh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1g5o 1g5o]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GJH FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gjh OCA], [https://pdbe.org/1gjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gjh RCSB], [https://www.ebi.ac.uk/pdbsum/1gjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gjh ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

[https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/1gjh_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gjh ConSurf].

*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Fesik SW]]

[[Category: Kim DH]]

[[Category: Matayoshi ED]]

[[Category: Medek A]]

[[Category: Nettesheim DG]]

[[Category: Oltersdorf T]]

[[Category: Petros AM]]

[[Category: Swift K]]

[[Category: Yoon HS]]