1eam: Difference between revisions
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==VACCINIA METHYLTRANSFERASE VP39 MUTANT (EC: 2.7.7.19)== | ==VACCINIA METHYLTRANSFERASE VP39 MUTANT (EC: 2.7.7.19)== | ||
<StructureSection load='1eam' size='340' side='right' caption='[[1eam]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1eam' size='340' side='right'caption='[[1eam]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1eam]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1eam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EAM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eam OCA], [https://pdbe.org/1eam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eam RCSB], [https://www.ebi.ac.uk/pdbsum/1eam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eam ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MCE_VACCW MCE_VACCW] Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.<ref>PMID:1313572</ref> <ref>PMID:1670500</ref> <ref>PMID:12359447</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</div> | </div> | ||
<div class="pdbe-citations 1eam" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1eam" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Poly(A) polymerase 3D structures|Poly(A) polymerase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
[[Category: Gershon | [[Category: Gershon PD]] | ||
[[Category: Hodel | [[Category: Hodel AE]] | ||
[[Category: Hu | [[Category: Hu G]] | ||
[[Category: Quiocho | [[Category: Quiocho FA]] | ||