1co0: Difference between revisions

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[[Image:1co0.gif|left|200px]]


<!--
==NMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEX==
The line below this paragraph, containing "STRUCTURE_1co0", creates the "Structure Box" on the page.
<StructureSection load='1co0' size='340' side='right'caption='[[1co0]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1co0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CO0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
{{STRUCTURE_1co0|  PDB=1co0  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1co0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1co0 OCA], [https://pdbe.org/1co0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1co0 RCSB], [https://www.ebi.ac.uk/pdbsum/1co0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1co0 ProSAT]</span></td></tr>
 
</table>
'''NMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEX'''
== Function ==
 
[https://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1CO0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CO0 OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/1co0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1co0 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Brocchieri, L.]]
[[Category: Brocchieri L]]
[[Category: Jardetzky, O.]]
[[Category: Jardetzky O]]
[[Category: Zhou, G P.]]
[[Category: Zhou GP]]
[[Category: Dna]]
[[Category: Dna-binding]]
[[Category: Peptide]]
[[Category: Repressor]]
[[Category: Transcription regulation]]
[[Category: Trp]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:56:12 2008''

Latest revision as of 02:28, 28 December 2023

NMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEXNMR STUDY OF TRP REPRESSOR-MTR OPERATOR DNA COMPLEX

Structural highlights

1co0 is a 4 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRPR_ECOLI This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Drag the structure with the mouse to rotate

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OCA
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