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Toll-like Receptor 3D structures: Difference between revisions

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New page: ==3D Structures of Toll-like Receptors== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Toll-like receptor 1 **[...
 
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==3D Structures of Toll-like Receptors==
==3D Structures of Toll-like Receptors==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} - For a general description of the protein see [[Toll-like Receptors]]
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|


*Toll-like receptor 1
*Toll-like receptor 1; Domains – Transmembrane+juxtamembrane 581-629; TIR 625-785; ligand-binding (LBD) 22-703; transmembrane 698-730


**[[1fyv]] – hTLR1 TIR domain – human<br />
**[[1fyv]] – hTLR1 TIR domain – human<br />
**[[6nih]] - hTLR1/VLRB.61<br />
**[[2z7x]], [[2z81]], [[2z82]] – hTLR1/VLRB.61 + hTLR2/VLRB.61 + lipopeptide
**[[2z7x]], [[2z81]], [[2z82]] – hTLR1/VLRB.61 + hTLR2/VLRB.61 + lipopeptide


*Toll-like receptor 2
*Toll-like receptor 2


**[[1fyw]] – hTLR2 TIR domain<br />
**[[8ar0]], [[8ar1]], [[8ar2]], [[8ar3]] – hTLR2 transmembrane+juxtamembrane domain – NMR<br />
**[[1fyw]], [[7nux]], [[7nux]] – hTLR2 TIR domain<br />
**[[7nt7]] – hTLR1 TIR domain – NMR<br />
**[[1fyx]], [[1o77]] - hTLR2 TIR domain (mutant) <br />
**[[1fyx]], [[1o77]] - hTLR2 TIR domain (mutant) <br />
**[[2z80]] – hTLR2/VLRB.61<br />
**[[2z80]] – hTLR2/VLRB.61<br />
**[[3a79]] – hTLR2/VLRB.61 + hTLR6/VLRB.61 + lipopeptide<br />
**[[3a79]] – hTLR2/VLRB.61 + hTLR6/VLRB.61 + lipopeptide<br />
**[[6nig]] – hTLR2/VLRB.61 + diprovocim<br />
**[[3a7b]] - mTLR2/VLRB.61 – mouse<br />
**[[3a7b]] - mTLR2/VLRB.61 – mouse<br />
**[[3a7c]] - mTLR2/VLRB.61 + PE-DTPA<br />
**[[3a7c]] - mTLR2/VLRB.61 + PE-DTPA<br />
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*Toll-like receptor 3
*Toll-like receptor 3


**[[1ziw]], [[2a0z]] – hTLR3 ligand-binding domain<br />
**[[1ziw]], [[2a0z]] – hTLR3 LBD<br />
**[[5gs0]] – hTLR3 ectodomain + antibody<br />
**[[5gs0]] – hTLR3 ectodomain + antibody<br />
**[[2mk9]], [[2mka]] – hTLR3 transmembrane domain - NMR <br />
**[[2mk9]], [[2mka]] – hTLR3 transmembrane domain - NMR <br />
**[[3cig]] – mTLR3 ectodomain<br />
**[[3ulv]], [[3ulu]], [[5gs0]] – hTLR3 LBD + antibody<br />
**[[3ciy]] - mTLR3 ectodomain + RNA<br />
**[[7c76]] – hTLR3 + UNC93B1 – Cryo EM<br />
**[[7wm4]], [[7wv3]], [[7wv4]], [[7wv5]], [[7wvj]] – hTLR3 LBD + RNA – Cryo EM<br />
**[[7wve]] – hTLR3 LBD (mutant) + RNA – Cryo EM<br />
**[[7wvf]] – hTLR3 LBD + antibody + RNA – Cryo EM<br />
**[[7c77]] – mTLR3 + UNC93B1 – Cryo EM<br />
**[[7da7]], [[7das]] – mTLR3 LBD + RNA – Cryo EM<br />
**[[3cig]] – mTLR3 LBD<br />
**[[3ciy]] - mTLR3 LBD + RNA<br />


*Toll-like receptor 4
*Toll-like receptor 4
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**[[3ul8]], [[3ul7]] – hTLR4/VLRB.61 (mutant)<br />
**[[3ul8]], [[3ul7]] – hTLR4/VLRB.61 (mutant)<br />
**[[5nam]], [[5nao]] – hTLR4 transmembrane domain - NMR<br />
**[[5nam]], [[5nao]] – hTLR4 transmembrane domain - NMR<br />
**[[3fxi]], [[4g8a]] - hTLR4 extracellular domain + lymphocyte antigen 96<br />
**[[3fxi]], [[4g8a]] - hTLR4 LBD + lymphocyte antigen 96<br />
**[[3ula]] - hTLR4/VLRB.61 + lymphocyte antigen 96<br />
**[[3ula]] - hTLR4/VLRB.61 + lymphocyte antigen 96<br />
**[[2z64]], [[2z65]], [[5ijc]], [[5ijd]], [[3vq1]], [[3vq2]] – mTLR4 extracellular domain+ lymphocyte antigen 96<br />
**[[2z64]], [[2z65]], [[5ijc]], [[5ijd]], [[3vq1]], [[3vq2]] – mTLR4 LBD + lymphocyte antigen 96<br />
**[[7mlm]] - mTLR4/VLRB.61 + lymphocyte antigen 96 + sulfatide<br />
 
*Toll-like receptor 5
 
**[[3j0a]] – hTLR5<br />
 
*Toll-like receptor 5A
 
**[[7b1b]], [[7b1c]], [[7b1d]] – TLR5A + Spz1C – yellow fever mosquito - Cryo EM<br />


*Toll-like receptor 5B
*Toll-like receptor 5B
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**[[6bxa]] – zfTLR5B N-terminal + VLR2 <br />
**[[6bxa]] – zfTLR5B N-terminal + VLR2 <br />
**[[6bxc]] – zfTLR5B N-terminal + VLR9 <br />
**[[6bxc]] – zfTLR5B N-terminal + VLR9 <br />
**[[3v44]] – zfTLR5B/VLRB.61 <br />
**[[3v44]], [[6bxa]], [[6bxc]] – zfTLR5B/VLRB.61 <br />
**[[3v47]] – zfTLR5B/VLRB.61 + flagellin<br />
**[[3v47]] – zfTLR5B/VLRB.61 + flagellin<br />


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*Toll-like receptor 7
*Toll-like receptor 7


**[[5gmf]] – mTLR7 + guanosine + poly-U - monkey <br />
**[[7cyn]] – hTLR7 + UNC93B1 – Cryo EM<br />
**[[5gmg]] – mTLR7 + loxoribine + poly-U  <br />
**[[5gmf]] – moTLR7 + guanosine + poly-U - monkey <br />
**[[5gmh]] – mTLR7 + resiquimod + poly-U  <br />
**[[5gmg]] – moTLR7 + loxoribine + poly-U  <br />
**[[5gmh]] – moTLR7 + resiquimod + poly-U  <br />
**[[5zsl]], [[5zsm]], [[5zsn]] – moTLR7 (mutant) + RNA <br />
**[[5zsg]], [[5zsh]], [[5zsi]], [[5zsj]], [[6lvz]], [[6lw1]], [[7ytp]] – moTLR7 (mutant) + inhibitor<br />
**[[6lvx]], [[6lvy]], [[6lw0]] – moTLR7 (mutant) + antagonist<br />
**[[6if5]] – moTLR7 (mutant) + cGMP<br />
**[[5zsf]] – moTLR7 (mutant) + drug<br />
**[[5zsa]], [[5zsb]], [[5zsd]], [[5zse]] – moTLR7 (mutant) + RNA + inhibitort<br />


*Toll-like receptor 8
*Toll-like receptor 8


**[[3w3g]], [[5hdh]] – hTLR8 <br />
**[[3w3g]], [[5hdh]] – hTLR8 <br />
**[[3w3j]], [[3w3k]], [[3w3l]], [[3w3m]], [[3w3n]], [[3wn4]], [[5awa]], [[5awc]], [[5awb]], [[5awd]], [[4r6a]], [[4qbz]], [[4qc0]], [[5az5]] – hTLR8 + agonist<br />
**[[3w3j]], [[3w3k]], [[3w3l]], [[3w3m]], [[3w3n]], [[3wn4]], [[5awa]], [[5awc]], [[5awb]], [[5awd]], [[4r6a]], [[4qbz]], [[4qc0]], [[5az5]], [[6v9u]], [[6wml]], [[6zjz]], [[7crf]], [[7r52]], [[7r53]], [[7r54]] – hTLR8 + agonist<br />
**[[6kya]], [[6ty5]], [[7rc9]], [[7ytx]], [[8pfi]] – hTLR8 + antagonist<br />
**[[4r07]], [[4r09]] – hTLR8 + ORN06 <br />
**[[4r07]], [[4r09]] – hTLR8 + ORN06 <br />
**[[4r08]] – hTLR8 + RNA <br />
**[[4r08]] – hTLR8 + RNA <br />
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**[[3wpg]], [[3wph]], [[3wpi]] – mTLR9 + DNA <br />
**[[3wpg]], [[3wph]], [[3wpi]] – mTLR9 + DNA <br />
**[[5zln]] – mTLR9 (mutant) + DNA <br />
**[[5zln]] – mTLR9 (mutant) + DNA <br />
**[[4qdh]] – mTLR9/VLRB.61 <br />
   
   
*Toll-like receptor 10
*Toll-like receptor 10
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**[[4z0c]] – mTLR13 + RNA <br />
**[[4z0c]] – mTLR13 + RNA <br />
*Toll-like receptor 15
**[[7ylf]], [[7ylg]] – TLR10 TIR domain - chicken<br />


  }}
  }}


[[Category:Topic Page]]
[[Category:Topic Page]]

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Michal Harel
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