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==Spatial Structure and Membrane Permeabilization for Latarcin-1, a Spider Antimicrobial Peptide==
==Spatial Structure and Membrane Permeabilization for Latarcin-1, a Spider Antimicrobial Peptide==
<StructureSection load='2pco' size='340' side='right' caption='[[2pco]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2pco' size='340' side='right'caption='[[2pco]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2pco]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PCO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2pco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lachesana_tarabaevi Lachesana tarabaevi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PCO FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2g9p|2g9p]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pco OCA], [http://pdbe.org/2pco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pco RCSB], [http://www.ebi.ac.uk/pdbsum/2pco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pco ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pco OCA], [https://pdbe.org/2pco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pco RCSB], [https://www.ebi.ac.uk/pdbsum/2pco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pco ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LAT1_LACTA LAT1_LACTA]] Has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.5 ug/ml), and B.subtilis VKM B-501 (MIC=1.0 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=1.0 ug/ml), E.coli MH1 (MIC=0.7 ug/ml), and P.aeruginosa PAO1 (MIC=4.1 ug/ml)), and yeasts (P.pastoris GS115 (MIC=17 ug/ml), and S.cerevisiae Y190 (MIC>33 ug/ml)). Has a moderate hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.  
[https://www.uniprot.org/uniprot/LAT1_LACTA LAT1_LACTA] Has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.5 ug/ml), and B.subtilis VKM B-501 (MIC=1.0 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=1.0 ug/ml), E.coli MH1 (MIC=0.7 ug/ml), and P.aeruginosa PAO1 (MIC=4.1 ug/ml)), and yeasts (P.pastoris GS115 (MIC=17 ug/ml), and S.cerevisiae Y190 (MIC>33 ug/ml)). Has a moderate hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arseniev, A S]]
[[Category: Lachesana tarabaevi]]
[[Category: Chupin, V V]]
[[Category: Large Structures]]
[[Category: Dubovskii, P V]]
[[Category: Arseniev AS]]
[[Category: Efremov, R G]]
[[Category: Chupin VV]]
[[Category: Polyansky, A A]]
[[Category: Dubovskii PV]]
[[Category: Volynsky, P E]]
[[Category: Efremov RG]]
[[Category: Continuous helix]]
[[Category: Polyansky AA]]
[[Category: Toxin]]
[[Category: Volynsky PE]]

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