2pco: Difference between revisions
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==Spatial Structure and Membrane Permeabilization for Latarcin-1, a Spider Antimicrobial Peptide== | ==Spatial Structure and Membrane Permeabilization for Latarcin-1, a Spider Antimicrobial Peptide== | ||
<StructureSection load='2pco' size='340' side='right' caption='[[2pco | <StructureSection load='2pco' size='340' side='right'caption='[[2pco]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2pco]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PCO OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[2pco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lachesana_tarabaevi Lachesana tarabaevi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PCO FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pco OCA], [https://pdbe.org/2pco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pco RCSB], [https://www.ebi.ac.uk/pdbsum/2pco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pco ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/LAT1_LACTA LAT1_LACTA] Has antimicrobial activity against Gram-positive bacteria (A.globiformis VKM Ac-1112 (MIC=0.5 ug/ml), and B.subtilis VKM B-501 (MIC=1.0 ug/ml)), Gram-negative bacteria (E.coli DH5-alpha (MIC=1.0 ug/ml), E.coli MH1 (MIC=0.7 ug/ml), and P.aeruginosa PAO1 (MIC=4.1 ug/ml)), and yeasts (P.pastoris GS115 (MIC=17 ug/ml), and S.cerevisiae Y190 (MIC>33 ug/ml)). Has a moderate hemolytic activity against rabbit erythrocytes. Causes paralysis, but is not lethal when injected into insect (Musca domestica) larvae. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Lachesana tarabaevi]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arseniev AS]] | ||
[[Category: | [[Category: Chupin VV]] | ||
[[Category: | [[Category: Dubovskii PV]] | ||
[[Category: | [[Category: Efremov RG]] | ||
[[Category: | [[Category: Polyansky AA]] | ||
[[Category: | [[Category: Volynsky PE]] |