2k1l: Difference between revisions

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 ==NMR structures of dimeric transmembrane domain of the receptor tyrosine kinase EphA1 in lipid bicelles at pH 6.3==
-<StructureSection load='2k1l' size='340' side='right' caption='[[2k1l]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>
+<StructureSection load='2k1l' size='340' side='right'caption='[[2k1l]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2k1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K1L FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2k1l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K1L FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPHA1, EPH, EPHT, EPHT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1l OCA], [https://pdbe.org/2k1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1l RCSB], [https://www.ebi.ac.uk/pdbsum/2k1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1l ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1l OCA], [http://pdbe.org/2k1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k1l RCSB], [http://www.ebi.ac.uk/pdbsum/2k1l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1l ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/EPHA1_HUMAN EPHA1_HUMAN]] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.<ref>PMID:17634955</ref> <ref>PMID:19118217</ref> <ref>PMID:20043122</ref>
+[https://www.uniprot.org/uniprot/EPHA1_HUMAN EPHA1_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.<ref>PMID:17634955</ref> <ref>PMID:19118217</ref> <ref>PMID:20043122</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 18: @@
 </div>
 <div class="pdbe-citations 2k1l" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Receptor protein-tyrosine kinase]]
+[[Category: Large Structures]]
-[[Category: Arseniev, A S]]
+[[Category: Arseniev AS]]
-[[Category: Bocharov, E V]]
+[[Category: Bocharov EV]]
-[[Category: Goncharuk, M V]]
+[[Category: Goncharuk MV]]
-[[Category: Mayzel, M L]]
+[[Category: Mayzel ML]]
-[[Category: Atp-binding]]
-[[Category: Dimeric transmembrane domain]]
-[[Category: Epha1]]
-[[Category: Glycoprotein]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Receptor tyrosine kinase]]
-[[Category: Signaling protein]]
-[[Category: Transferase]]
-[[Category: Tyrosine-protein kinase]]