4uf5: Difference between revisions

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 ==Crystal structure of UCH-L5 in complex with inhibitory fragment of INO80G==
-<StructureSection load='4uf5' size='340' side='right' caption='[[4uf5]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
+<StructureSection load='4uf5' size='340' side='right'caption='[[4uf5]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4uf5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UF5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4uf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UF5 FirstGlance]. <br>
-</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uf5 OCA], [http://pdbe.org/4uf5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uf5 RCSB], [http://www.ebi.ac.uk/pdbsum/4uf5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uf5 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uf5 OCA], [https://pdbe.org/4uf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uf5 RCSB], [https://www.ebi.ac.uk/pdbsum/4uf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uf5 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/UCHL5_HUMAN UCHL5_HUMAN]] Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.<ref>PMID:16906146</ref> <ref>PMID:18922472</ref>  [[http://www.uniprot.org/uniprot/NFRKB_HUMAN NFRKB_HUMAN]] Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.<ref>PMID:18922472</ref>   Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.<ref>PMID:18922472</ref>
+[https://www.uniprot.org/uniprot/UCHL5_HUMAN UCHL5_HUMAN] Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.<ref>PMID:16906146</ref> <ref>PMID:18922472</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 20: @@
 ==See Also==
-*[[Thioesterase|Thioesterase]]
+*[[Thioesterase 3D structures|Thioesterase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ubiquitinyl hydrolase 1]]
+[[Category: Homo sapiens]]
-[[Category: Dijk, W J.Van]]
+[[Category: Large Structures]]
-[[Category: Ekkebus, R]]
+[[Category: Ekkebus R]]
-[[Category: Oualid, F El]]
+[[Category: El Oualid F]]
-[[Category: Ovaa, H]]
+[[Category: Ovaa H]]
-[[Category: Sahtoe, D D]]
+[[Category: Sahtoe DD]]
-[[Category: Sixma, T K]]
+[[Category: Sixma TK]]
-[[Category: Deubiquitinating enzyme]]
+[[Category: Van Dijk WJ]]
-[[Category: Hydrolase]]