4ue9: Difference between revisions

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-==Complex OF D. melanogaster EIF4E with the 4E binding protein 4E-T==
-<StructureSection load='4ue9' size='340' side='right' caption='[[4ue9]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+==Complex of D. melanogaster eIF4E with the 4E-binding protein 4E-T==
+<StructureSection load='4ue9' size='340' side='right'caption='[[4ue9]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ue9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UE9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ue9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UE9 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ue8|4ue8]], [[4uea|4uea]], [[4ueb|4ueb]], [[4uec|4uec]], [[4ued|4ued]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ue9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ue9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ue9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ue9 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ue9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ue9 OCA], [https://pdbe.org/4ue9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ue9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ue9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ue9 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/IF4E_DROME IF4E_DROME]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.<ref>PMID:8663200</ref>
+[https://www.uniprot.org/uniprot/IF4E_DROME IF4E_DROME] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.<ref>PMID:8663200</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The eIF4E-binding proteins (4E-BPs) represent a diverse class of translation inhibitors that are often deregulated in cancer cells. 4E-BPs inhibit translation by competing with eIF4G for binding to eIF4E through an interface that consists of canonical and non-canonical eIF4E-binding motifs connected by a linker. The lack of high-resolution structures including the linkers, which contain phosphorylation sites, limits our understanding of how phosphorylation inhibits complex formation. Furthermore, the binding mechanism of the non-canonical motifs is poorly understood. Here, we present structures of human eIF4E bound to 4E-BP1 and fly eIF4E bound to Thor, 4E-T, and eIF4G. These structures reveal architectural elements that are unique to 4E-BPs and provide insight into the consequences of phosphorylation. Guided by these structures, we designed and crystallized a 4E-BP mimic that shows increased repressive activity. Our studies pave the way for the rational design of 4E-BP mimics as therapeutic tools to decrease translation during oncogenic transformation.
+Molecular Architecture of 4E-BP Translational Inhibitors Bound to eIF4E.,Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, Weichenrieder O, Izaurralde E Mol Cell. 2015 Feb 18. pii: S1097-2765(15)00018-0. doi:, 10.1016/j.molcel.2015.01.017. PMID:25702871<ref>PMID:25702871</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4ue9" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Peter, D]]
+[[Category: Drosophila melanogaster]]
-[[Category: Weichenrieder, O]]
+[[Category: Large Structures]]
-[[Category: 4e binding protein]]
+[[Category: Peter D]]
-[[Category: Cap binding protein]]
+[[Category: Weichenrieder O]]
-[[Category: Gene regulation]]
-[[Category: Translation]]
-[[Category: Translational repression]]