4d75: Difference between revisions

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 ==Cytochrome P450 3A4 bound to an inhibitor==
-<StructureSection load='4d75' size='340' side='right' caption='[[4d75]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
+<StructureSection load='4d75' size='340' side='right'caption='[[4d75]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4d75]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D75 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4d75]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D75 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PK9:TERT-BUTYL+{6-OXO-6-[(PYRIDIN-3-YLMETHYL)AMINO]HEXYL}CARBAMATE'>PK9</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d6z|4d6z]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PK9:TERT-BUTYL+{6-OXO-6-[(PYRIDIN-3-YLMETHYL)AMINO]HEXYL}CARBAMATE'>PK9</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d75 OCA], [http://pdbe.org/4d75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d75 RCSB], [http://www.ebi.ac.uk/pdbsum/4d75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d75 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d75 OCA], [https://pdbe.org/4d75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d75 RCSB], [https://www.ebi.ac.uk/pdbsum/4d75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d75 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
+[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 ==See Also==
-*[[Cytochrome P450|Cytochrome P450]]
+*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Poulos, T]]
+[[Category: Large Structures]]
-[[Category: Sevrioukova, I]]
+[[Category: Poulos T]]
-[[Category: Inhibitory complex]]
+[[Category: Sevrioukova I]]
-[[Category: Monooxygenase]]
-[[Category: Oxidoreductase]]