4d1b: Difference between revisions

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 ==STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH BENZYL-HYDANTOIN==
-<StructureSection load='4d1b' size='340' side='right' caption='[[4d1b]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
+<StructureSection load='4d1b' size='340' side='right'caption='[[4d1b]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4d1b]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jlo 2jlo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D1B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4d1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Microbacterium_liquefaciens Microbacterium liquefaciens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jlo 2jlo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D1B FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5FH:(5S)-5-BENZYLIMIDAZOLIDINE-2,4-DIONE'>5FH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d1a|4d1a]], [[4d1c|4d1c]], [[4d1d|4d1d]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5FH:(5S)-5-BENZYLIMIDAZOLIDINE-2,4-DIONE'>5FH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1b OCA], [http://pdbe.org/4d1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d1b RCSB], [http://www.ebi.ac.uk/pdbsum/4d1b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d1b ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1b OCA], [https://pdbe.org/4d1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d1b RCSB], [https://www.ebi.ac.uk/pdbsum/4d1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d1b ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/HYUP_MICLQ HYUP_MICLQ] Nucleobase-proton symporter that mediates the sodium-dependent binding and uptake of 5-aryl-substituted hydantoin compounds (PubMed:16621827, PubMed:24952894). 5-indolyl methyl hydantoin and 5-benzyl hydantoin are the preferred substrates, with selectivity for a hydrophobic substituent in position 5 of hydantoin and for the L isomer over the D isomer (PubMed:16621827, PubMed:24952894).<ref>PMID:16621827</ref> <ref>PMID:24952894</ref> <ref>PMID:16116274</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Brueckner, F]]
+[[Category: Large Structures]]
-[[Category: Cameron, A D]]
+[[Category: Microbacterium liquefaciens]]
-[[Category: Drew, D]]
+[[Category: Brueckner F]]
-[[Category: Geng, T]]
+[[Category: Cameron AD]]
-[[Category: Henderson, P J.F]]
+[[Category: Drew D]]
-[[Category: Iwata, S]]
+[[Category: Geng T]]
-[[Category: Weyand, S]]
+[[Category: Henderson PJF]]
-[[Category: Membrane protein transporter]]
+[[Category: Iwata S]]
-[[Category: Occluded state]]
+[[Category: Weyand S]]
-[[Category: Substrate-bound]]
-[[Category: Transport protein]]