4d11: Difference between revisions

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 ==GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 peptide and manganese (Lower resolution dataset)==
-<StructureSection load='4d11' size='340' side='right' caption='[[4d11]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
+<StructureSection load='4d11' size='340' side='right'caption='[[4d11]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4d11]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D11 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4d11]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D11 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BBK:2-(ACETYLAMINO)-2-DEOXY-5-THIO-ALPHA-D-GALACTOPYRANOSE'>BBK</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d0t|4d0t]], [[4d0z|4d0z]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BBK:2-(ACETYLAMINO)-2-DEOXY-5-THIO-ALPHA-D-GALACTOPYRANOSE'>BBK</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d11 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d11 RCSB], [http://www.ebi.ac.uk/pdbsum/4d11 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d11 OCA], [https://pdbe.org/4d11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d11 RCSB], [https://www.ebi.ac.uk/pdbsum/4d11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d11 ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4d11" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Clausen, H.]]
+[[Category: Homo sapiens]]
-[[Category: Companon, I.]]
+[[Category: Large Structures]]
-[[Category: Corzana, F.]]
+[[Category: Clausen H]]
-[[Category: Hurtado-Guerrero, R.]]
+[[Category: Companon I]]
-[[Category: Iglesias-Fernandez, J.]]
+[[Category: Corzana F]]
-[[Category: Kong, Y.]]
+[[Category: Hurtado-Guerrero R]]
-[[Category: Lira-Navarrete, E.]]
+[[Category: Iglesias-Fernandez J]]
-[[Category: Peregrina, J M.]]
+[[Category: Kong Y]]
-[[Category: Pinto, B M.]]
+[[Category: Lira-Navarrete E]]
-[[Category: Rovira, C.]]
+[[Category: Peregrina JM]]
-[[Category: Vocadlo, D.]]
+[[Category: Pinto BM]]
-[[Category: Zandberg, W F.]]
+[[Category: Rovira C]]
-[[Category: Acetamido group]]
+[[Category: Vocadlo D]]
-[[Category: Bi-bi kinetic mechanism]]
+[[Category: Zandberg WF]]
-[[Category: Qm/mm metadynamic]]
-[[Category: Retaining galnac-t2]]
-[[Category: Substrate specificity]]
-[[Category: Substrate-guided sni-type reaction]]
-[[Category: Transferase-peptide complex]]