4cym: Difference between revisions

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 ==Complex of human VARP-ANKRD1 with Rab32-GppCp==
-<StructureSection load='4cym' size='340' side='right' caption='[[4cym]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+<StructureSection load='4cym' size='340' side='right'caption='[[4cym]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4cym]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CYM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4cym]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYM FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cz2|4cz2]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cym OCA], [https://pdbe.org/4cym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cym RCSB], [https://www.ebi.ac.uk/pdbsum/4cym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cym ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cym OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cym RCSB], [http://www.ebi.ac.uk/pdbsum/4cym PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/RAB32_HUMAN RAB32_HUMAN] Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:12186851</ref> <ref>PMID:21255211</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 VARP Is Recruited on to Endosomes by Direct Interaction with Retromer, Where Together They Function in Export to the Cell Surface.,Hesketh GG, Perez-Dorado I, Jackson LP, Wartosch L, Schafer IB, Gray SR, McCoy AJ, Zeldin OB, Garman EF, Harbour ME, Evans PR, Seaman MN, Luzio JP, Owen DJ Dev Cell. 2014 May 21. pii: S1534-5807(14)00230-5. doi:, 10.1016/j.devcel.2014.04.010. PMID:24856514<ref>PMID:24856514</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4cym" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ankyrin repeat domain-containing protein 3D structures|Ankyrin repeat domain-containing protein 3D structures]]
+*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Small monomeric GTPase]]
+[[Category: Homo sapiens]]
-[[Category: Evans, P R.]]
+[[Category: Large Structures]]
-[[Category: McCoy, A J.]]
+[[Category: Evans PR]]
-[[Category: Owen, D J.]]
+[[Category: McCoy AJ]]
-[[Category: Perez-Dorado, I.]]
+[[Category: Owen DJ]]
-[[Category: Schaefer, I B.]]
+[[Category: Perez-Dorado I]]
-[[Category: Endosome]]
+[[Category: Schaefer IB]]
-[[Category: Melanosome biogenesis]]
-[[Category: Rab]]
-[[Category: Rab-effector]]
-[[Category: Transport protein]]
-[[Category: Varp]]
-[[Category: Vesicle trafficking]]