4cxa: Difference between revisions

<StructureSection load='4cxa' size='340' side='right'caption='[[4cxa]], [[Resolution|resolution]] 3.15&Aring;' scene=''>

<table><tr><td colspan='2'>[[4cxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CXA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxa OCA], [https://pdbe.org/4cxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cxa RCSB], [https://www.ebi.ac.uk/pdbsum/4cxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cxa ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.

[https://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref>  

*[[Cyclin 3D structures|Cyclin 3D structures]]

*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith C]]

[[Category: Bountra C]]

[[Category: Bullock A]]

[[Category: Burgess-Brown N]]

[[Category: Carpenter EP]]

[[Category: Dixon Clarke SE]]

[[Category: Edwards AM]]

[[Category: Elkins JM]]

[[Category: Faust B]]

[[Category: Froese S]]

[[Category: Goubin S]]

[[Category: Kopec J]]

[[Category: Mackenzie A]]

[[Category: Mahajan RP]]

[[Category: Nowak R]]

[[Category: Pike ACW]]

[[Category: Tallant C]]

[[Category: Von Delft F]]