4cth: Difference between revisions

<StructureSection load='4cth' size='340' side='right'caption='[[4cth]], [[Resolution|resolution]] 2.15&Aring;' scene=''>

<table><tr><td colspan='2'>[[4cth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CTH FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RDF:N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN'>RDF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cth OCA], [https://pdbe.org/4cth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cth RCSB], [https://www.ebi.ac.uk/pdbsum/4cth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cth ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/NEP_HUMAN NEP_HUMAN] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.<ref>PMID:2531377</ref> <ref>PMID:15283675</ref> <ref>PMID:20876573</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Andersson C]]

[[Category: Burrell M]]

[[Category: Digby S]]

[[Category: Fowler SB]]

[[Category: Grudzinska J]]

[[Category: Haupts U]]

[[Category: Jermutus L]]

[[Category: Olsson L]]

[[Category: Sandercock A]]

[[Category: Snijder A]]

[[Category: Tebbe J]]

[[Category: Webster CI]]