4ct0: Difference between revisions

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OCA

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 ==Crystal Structure of Mouse Cryptochrome1 in Complex with Period2==
-<StructureSection load='4ct0' size='340' side='right' caption='[[4ct0]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
+<StructureSection load='4ct0' size='340' side='right'caption='[[4ct0]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ct0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CT0 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ct0 PDBsum]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<table>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ct0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ct0 OCA], [https://pdbe.org/4ct0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ct0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ct0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ct0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CRY1_MOUSE CRY1_MOUSE] Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.<ref>PMID:10428031</ref> <ref>PMID:16628007</ref> <ref>PMID:16478995</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 12: / Line 16: @@
 Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation.,Schmalen I, Reischl S, Wallach T, Klemz R, Grudziecki A, Prabu JR, Benda C, Kramer A, Wolf E Cell. 2014 May 22;157(5):1203-15. doi: 10.1016/j.cell.2014.03.057. PMID:24855952<ref>PMID:24855952</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4ct0" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Cryptochrome 3D structures|Cryptochrome 3D structures]]
+*[[Period circadian protein|Period circadian protein]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Benda, C.]]
+[[Category: Large Structures]]
-[[Category: Prabu, J Rajan.]]
+[[Category: Mus musculus]]
-[[Category: Schmalen, I.]]
+[[Category: Benda C]]
-[[Category: Wolf, E.]]
+[[Category: Rajan Prabu J]]
-[[Category: Circadian clock protein]]
+[[Category: Schmalen I]]
-[[Category: Cryptochrome interaction]]
+[[Category: Wolf E]]
-[[Category: Cryptochrome-period complex]]
-[[Category: Disulfide bond]]
-[[Category: Redox regulation]]
-[[Category: Zinc interface]]