4ckr: Difference between revisions

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==Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1==
==Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1==
<StructureSection load='4ckr' size='340' side='right' caption='[[4ckr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4ckr' size='340' side='right'caption='[[4ckr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ckr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bki 4bki]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CKR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ckr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bki 4bki]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CKR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI1:4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]-N-{4-METHYL-3-[(2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)OXY]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE'>DI1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DI1:4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]-N-{4-METHYL-3-[(2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)OXY]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE'>DI1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ckr OCA], [http://pdbe.org/4ckr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ckr RCSB], [http://www.ebi.ac.uk/pdbsum/4ckr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ckr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ckr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ckr OCA], [https://pdbe.org/4ckr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ckr RCSB], [https://www.ebi.ac.uk/pdbsum/4ckr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ckr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DDR1_HUMAN DDR1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ckr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ckr" style="background-color:#fffaf0;"></div>
==See Also==
*[[Epithelial discoidin domain-containing receptor|Epithelial discoidin domain-containing receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Bullock, A]]
[[Category: Bullock A]]
[[Category: Canning, P]]
[[Category: Canning P]]
[[Category: Chaikuad, A]]
[[Category: Chaikuad A]]
[[Category: Delft, F von]]
[[Category: Dixon-Clarke S]]
[[Category: Dixon-Clarke, S]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Elkins JM]]
[[Category: Elkins, J M]]
[[Category: Goubin S]]
[[Category: Goubin, S]]
[[Category: Krojer T]]
[[Category: Krojer, T]]
[[Category: Mahajan P]]
[[Category: Mahajan, P]]
[[Category: Newman JA]]
[[Category: Newman, J A]]
[[Category: Von Delft F]]
[[Category: Collagen]]
[[Category: Discoidin domain]]
[[Category: Transferase]]

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