4chb: Difference between revisions

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 ==Crystal structure of the human KLHL2 Kelch domain in complex with a WNK4 peptide==
-<StructureSection load='4chb' size='340' side='right'  caption='[[4chb]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
+<StructureSection load='4chb' size='340' side='right'caption='[[4chb]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4chb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4chb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CHB FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ch9|4ch9]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chb OCA], [https://pdbe.org/4chb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4chb RCSB], [https://www.ebi.ac.uk/pdbsum/4chb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4chb ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chb OCA], [http://pdbe.org/4chb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4chb RCSB], [http://www.ebi.ac.uk/pdbsum/4chb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4chb ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/WNK4_HUMAN WNK4_HUMAN]] Defects in WNK4 are a cause of pseudohypoaldosteronism type 2B (PHA2B) [MIM:[http://omim.org/entry/614491 614491]]. PHAII is an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron.<ref>PMID:11498583</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/KLHL2_HUMAN KLHL2_HUMAN]] May play a role in organizing the actin cytoskeleton of the brain cells. [[http://www.uniprot.org/uniprot/WNK4_HUMAN WNK4_HUMAN]] Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L.<ref>PMID:20525693</ref>
+[https://www.uniprot.org/uniprot/KLHL2_HUMAN KLHL2_HUMAN] May play a role in organizing the actin cytoskeleton of the brain cells.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 21: @@
 ==See Also==
-*[[Kelch-like protein|Kelch-like protein]]
+*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Alessi, D R]]
+[[Category: Alessi DR]]
-[[Category: Arrowsmith, C H]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C]]
+[[Category: Bountra C]]
-[[Category: Bullock, A]]
+[[Category: Bullock A]]
-[[Category: Canning, P]]
+[[Category: Canning P]]
-[[Category: Cooper, C D.O]]
+[[Category: Cooper CDO]]
-[[Category: Delft, F von]]
+[[Category: Edwards AM]]
-[[Category: Edwards, A M]]
+[[Category: Kopec J]]
-[[Category: Kopec, J]]
+[[Category: Krojer T]]
-[[Category: Krojer, T]]
+[[Category: Kurz T]]
-[[Category: Kurz, T]]
+[[Category: Newman J]]
-[[Category: Newman, J]]
+[[Category: Schumacher FR]]
-[[Category: Schumacher, F R]]
+[[Category: Sorrell FJ]]
-[[Category: Sorrell, F J]]
+[[Category: Williams E]]
-[[Category: Williams, E]]
+[[Category: Von Delft F]]
-[[Category: Adaptor protein]]
-[[Category: Kelch repeat]]
-[[Category: Klhl3]]
-[[Category: Protein-binding]]
-[[Category: Signaling protein-transferase complex]]
-[[Category: Ubiquitin]]
-[[Category: Wnk signalling pathway]]