4cet: Difference between revisions
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==Crystal structure of the complex of the P187S variant of human NAD(P) H:quinone oxidoreductase with dicoumarol at 2.2 A resolution== | ==Crystal structure of the complex of the P187S variant of human NAD(P) H:quinone oxidoreductase with dicoumarol at 2.2 A resolution== | ||
<StructureSection load='4cet' size='340' side='right' caption='[[4cet]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4cet' size='340' side='right'caption='[[4cet]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cet]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CET OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4cet]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CET FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTC:BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE]'>DTC</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTC:BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE]'>DTC</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cet OCA], [https://pdbe.org/4cet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cet RCSB], [https://www.ebi.ac.uk/pdbsum/4cet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cet ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NQO1_HUMAN NQO1_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 15: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4cet" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[NADPH dehydrogenase|NADPH dehydrogenase]] | |||
*[[Quinone reductase 3D structures|Quinone reductase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Binter | [[Category: Homo sapiens]] | ||
[[Category: Gruber | [[Category: Large Structures]] | ||
[[Category: Gudipati | [[Category: Binter A]] | ||
[[Category: Lienhart | [[Category: Gruber K]] | ||
[[Category: Macheroux | [[Category: Gudipati V]] | ||
[[Category: Pulido | [[Category: Lienhart WD]] | ||
[[Category: Saf | [[Category: Macheroux P]] | ||
[[Category: Uhl | [[Category: Pulido S]] | ||
[[Category: Zangger | [[Category: Saf R]] | ||
[[Category: Uhl MK]] | |||
[[Category: Zangger K]] | |||