4cbi: Difference between revisions
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<StructureSection load='4cbi' size='340' side='right'caption='[[4cbi]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='4cbi' size='340' side='right'caption='[[4cbi]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cbi]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4cbi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Classical_swine_fever_virus Classical swine fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CBI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbi OCA], [https://pdbe.org/4cbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cbi RCSB], [https://www.ebi.ac.uk/pdbsum/4cbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cbi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/POLG_CSFVA POLG_CSFVA] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4cbi" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4cbi" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Helicase 3D structures|Helicase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Classical swine fever virus]] | [[Category: Classical swine fever virus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bricogne | [[Category: Bricogne G]] | ||
[[Category: Duquerroy | [[Category: Duquerroy S]] | ||
[[Category: Kwok | [[Category: Kwok J]] | ||
[[Category: Lamp | [[Category: Lamp B]] | ||
[[Category: Perez | [[Category: Perez J]] | ||
[[Category: Rey | [[Category: Rey FA]] | ||
[[Category: Rumenapf | [[Category: Rumenapf T]] | ||
[[Category: Tortorici | [[Category: Tortorici MA]] | ||
[[Category: Vachette | [[Category: Vachette P]] | ||
[[Category: Vonrhein | [[Category: Vonrhein C]] | ||