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==Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)==
==Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)==
<StructureSection load='4c8d' size='340' side='right' caption='[[4c8d]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
<StructureSection load='4c8d' size='340' side='right'caption='[[4c8d]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C8D FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C8D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8d OCA], [http://pdbe.org/4c8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c8d RCSB], [http://www.ebi.ac.uk/pdbsum/4c8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8d ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8d OCA], [https://pdbe.org/4c8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c8d RCSB], [https://www.ebi.ac.uk/pdbsum/4c8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KDM3B_HUMAN KDM3B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.<ref>PMID:16603237</ref>
[https://www.uniprot.org/uniprot/KDM3B_HUMAN KDM3B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.<ref>PMID:16603237</ref>  
 
==See Also==
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Crawley, L]]
[[Category: Bountra C]]
[[Category: Delft, F von]]
[[Category: Crawley L]]
[[Category: Edwards, A]]
[[Category: Edwards A]]
[[Category: Gileadi, C]]
[[Category: Gileadi C]]
[[Category: Goubin, S]]
[[Category: Goubin S]]
[[Category: Johansson, C]]
[[Category: Johansson C]]
[[Category: Krojer, T]]
[[Category: Krojer T]]
[[Category: Oppermann, U]]
[[Category: Oppermann U]]
[[Category: Szykowska, A]]
[[Category: Szykowska A]]
[[Category: Vollmar, M]]
[[Category: Vollmar M]]
[[Category: Oxidoreductase]]
[[Category: Von Delft F]]

Latest revision as of 15:05, 20 December 2023

Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)

Structural highlights

4c8d is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.18Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KDM3B_HUMAN Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.[1]

See Also

References

  1. ↑ Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell. 2006 May 5;125(3):483-95. Epub 2006 Apr 6. PMID:16603237 doi:http://dx.doi.org/S0092-8674(06)00385-0

4c8d, resolution 2.18Å

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