4c53: Difference between revisions
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<StructureSection load='4c53' size='340' side='right'caption='[[4c53]], [[Resolution|resolution]] 4.14Å' scene=''> | <StructureSection load='4c53' size='340' side='right'caption='[[4c53]], [[Resolution|resolution]] 4.14Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4c53]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4c53]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Guanarito_mammarenavirus Guanarito mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C53 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.14Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c53 OCA], [https://pdbe.org/4c53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c53 RCSB], [https://www.ebi.ac.uk/pdbsum/4c53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c53 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GLYC_GTOVV GLYC_GTOVV] Interacts with the host receptor (By similarity). Mediates virus attachment to host TFRC. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis (PubMed:17287727).[HAMAP-Rule:MF_04084]<ref>PMID:17287727</ref> Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced upon acidification in the endosome.[HAMAP-Rule:MF_04084] Stable signal peptide (SSP): cleaved and functions as a signal peptide. In addition, it is also retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.[HAMAP-Rule:MF_04084] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4c53" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4c53" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Guanarito mammarenavirus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bowden | [[Category: Bowden TA]] | ||
[[Category: Harlos | [[Category: Harlos K]] | ||
[[Category: Huiskonen | [[Category: Huiskonen JT]] | ||
[[Category: Parsy | [[Category: Parsy M]] | ||