4c49: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
m Protected "4c49" [edit=sysop:move=sysop]
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 4c49 is ON HOLD
==Reactive loop cleaved human CBG in complex with cortisol==
<StructureSection load='4c49' size='340' side='right'caption='[[4c49]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4c49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C49 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HCY:(11ALPHA,14BETA)-11,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE'>HCY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c49 OCA], [https://pdbe.org/4c49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c49 RCSB], [https://www.ebi.ac.uk/pdbsum/4c49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c49 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CBG_HUMAN CBG_HUMAN] Corticosteroid-binding globulin deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CBG_HUMAN CBG_HUMAN] Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.<ref>PMID:18513745</ref>


Authors: Chan, W.L., Zhou, A., Read, R.J.
==See Also==
 
*[[Corticosteroid-binding globulin|Corticosteroid-binding globulin]]
Description: Reactive loop cleaved human CBG in complex with cortisol
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chan WL]]
[[Category: Read RJ]]
[[Category: Zhou A]]

Latest revision as of 15:03, 20 December 2023

Reactive loop cleaved human CBG in complex with cortisolReactive loop cleaved human CBG in complex with cortisol

Structural highlights

4c49 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CBG_HUMAN Corticosteroid-binding globulin deficiency. The disease is caused by mutations affecting the gene represented in this entry.

Function

CBG_HUMAN Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.[1]

See Also

References

  1. Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RW. The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J Mol Biol. 2008 Jun 27;380(1):244-51. Epub 2008 May 14. PMID:18513745 doi:10.1016/j.jmb.2008.05.012

4c49, resolution 2.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA